Biological Chemistry, Volume 392, Issue 10, Page 837-847, October 2011. more
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The Nicastrin ectodomain adopts a highly thermostable structure
Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins Nicastrin, anterior pharynx-defective-1 (Aph-1), presenilin enhancer-2 (Pen-2) and Presenilin are essential to form the active γ-secretase complex. Recently it has been shown, that Nicastrin has a key function in stabilizing the mature γ-secretase complex and may also be involved in substrate recognition. So far no structural data for the Nicastrin ectodomain or any other γ-secretase component are available. We therefore used Circular Dichroism (CD) spectroscopy to demonstrate that Nicastrin, similar to its homologues, the Streptomyces griseus aminopeptidase (SGAP) and the transferrin receptor (TfR), adopts a thermostable secondary structure. Furthermore, the Nicastrin ectodomain has an exceptionally high propensity t...
| Authors: | Regina Fluhrer; Frits Kamp; Gudula Grammer; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass | |
| Journal: | Biological Chemistry | |
| Year: | 2011 | |
| DOI: | 10.1515/BC.2011.169 | |
| Publication date: | 06-Oct-2011 |
Facts, background information, dossiers
- spectroscopy
- proteins
- molecular weight
- Alzheimer's disease
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