Biological Chemistry, Volume 392, Issue 10, Page 837-847, October 2011. more
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Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites
Abstract Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an automated and simple web-based data-analysis resource termed WebPics (http://clipserve.clip.ubc.ca/pics/). We demonstrate the utility of WebPics analysis of PICS data by determining the substrate specificity of factor Xa from P6-P6’, an important blood coagulation protease that proteolytically generates thrombin from prothrombin. PICS confirms existing data on non-prime site specificity and refines our knowledge of factor Xa prime-site selectivity.
| Authors: | Oliver Schilling; Ulrich auf dem Keller; Christopher M. Overall | |
| Journal: | Biological Chemistry | |
| Year: | 2011 | |
| DOI: | 10.1515/BC.2011.158 | |
| Publication date: | 06-Oct-2011 |
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