Biological Chemistry, Volume 392, Issue 10, Page 837-847, October 2011. more
To use all functions of this page, please activate cookies in your browser.
My watch list
my.chemeurope.com
my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites
Abstract Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an automated and simple web-based data-analysis resource termed WebPics (http://clipserve.clip.ubc.ca/pics/). We demonstrate the utility of WebPics analysis of PICS data by determining the substrate specificity of factor Xa from P6-P6’, an important blood coagulation protease that proteolytically generates thrombin from prothrombin. PICS confirms existing data on non-prime site specificity and refines our knowledge of factor Xa prime-site selectivity.
| Authors: | Oliver Schilling; Ulrich auf dem Keller; Christopher M. Overall | |
| Journal: | Biological Chemistry | |
| Year: | 2011 | |
| DOI: | 10.1515/BC.2011.158 | |
| Publication date: | 06-Oct-2011 |
Facts, background information, dossiers
More about de Gruyter
- Publications
-
News
Is it time to abandon the Nobel Prize?
In a commentary piece authors Clare Fiala and Eleftherios P. Diamandis spawned a debate now further nourished by recent disclosures. Fiala and Diamandis argue that it is time to abandon the Nobel Prize in favor of alternative recognitions which encompass the collaborative nature of modern s ... more
-
Companies
Walter de Gruyter GmbH & Co. KG
The scholarly publishing house of Walter de Gruyter has for decades been synonymous with superior academic and scientific literature. Annually, we publish more than 250 new books, over 60 academic journals, as well as various electronic media. As we cater to the academic world, de Gruyter f ... more
