Electronic noses calibration procedure in the context of a multicentre medical study
An overview of the scientific literature in the medical field tells us that a large part of electronic nose applications is devoted to breath analysis. A network based study can help testing the validity of this strategy when using many different devices based on identical or different technologies, in view of a use in real clinical practice. The first step is the instrument calibration using a set of key-compounds. In this work a gas sensor array based on Quartz Micro Balance transducers functionalized with metallo-porphyrins (ROTV e-nose), and a Cyranose are used simultaneously in a calibration experiment with three ad hoc selected compounds: ethanol, hexane and ethyl acetate, at concentration levels around 1ppm. These tests have demonstrated that Limits of detection down to tens of ppb are possible. Moreover, a mapping between the two instruments has been performed through the calculation of a model based on Cyranose data, and applied to the ROTV e-nose data, for the prediction of compound concentrations. This test has shown a good ability in concentrations prediction, with an error lower than 10 ppb. In conclusion, this study provides the first step towards quality assurance of eNose data in the medical setting.
M. Santonico, G. Pennazza, R. Capuano, C. Falconi, T.J. Vink, H.H. Knobel, M.P. Van der Schee, P.J. Sterk, P. Montuschi, A. D’Amico
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