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The therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer

For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alternative therapies and the use of natural products. This review emphasizes recent studies involving naturally occurring antiulcer metabolites, categorized according to their chemical structure. Both terrestrial and marine sources are included. More than a hundred and fifty different compounds are presented, and where possible, their main mechanisms of action are summarized. Considering that Helicobacter pylori is an important causal factor in the pathogenesis of ulcer disease, an overview of some natural compounds with anti-H. pylori activity is presented.

Authors:   Luiz Carlos Klein-Júnior, José Roberto Santin, Rivaldo Niero, Sérgio Faloni de Andrade, Valdir Cechinel-Filho
Journal:   Phytochemistry Reviews
Year:   2012
Pages:   1
DOI:   10.1007/s11101-012-9262-4
Publication date:   27-Nov-2012
Facts, background information, dossiers
  • ulcer
  • Proton
  • peptic ulcer
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