Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites
Endophytic fungi are ubiquitous organisms found in the plants, residing intercellular or intracellular, at least for a portion of their lives without causing apparent symptoms of infection. Almost all plants are known to harbor endophytes. The choice of the plant to be used for exploring endophytes for bioactives is important. Therefore, medicinal plants which are known to be used since centuries as an alternative source of medicine, are a valuable source for bioprospecting endophytes. Nevertheless, due to many reasons there is a dire need for novel resources for novel drugs which can be an answer to many deadly diseases. It is in this context that the present review was envisaged. The review reveals the importance of endophytic fungi from medicinal plants as a source of bioactive and chemically novel compounds. The bioactive metabolites produced by endophytic fungi originate from different biosynthetic pathways and belong to diverse structural groups such as terpenoids, steroids, quinones, phenols, coumarins etc. Endophytes therefore, represent a chemical reservoir for new compounds such as, anticancer, immunomodulatory, antioxidant, antiparasitic, antiviral, antitubercular, insecticidal etc. for use in the pharmaceutical and agrochemical industries. Although, efforts have been made to accommodate as many examples as possible but the depth of the subject is so vast that it cannot be covered in one single review. This in itself speaks of the fact that endophytic fungi from medicinal plants is indeed a treasure worth searching. In the present review only some selected examples have been covered.
Sanjana Kaul, Suruchi Gupta, Maroof Ahmed, Manoj K. Dhar
Plant parasitic nematodes are the most destructive group of plant pathogens worldwide and their control is extremely challenging. Plant Essential oils (EOs) and their constituents have a great potential in nematode control since they can be developed for use as nematicides themselves or can ... more
For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alt ... more
Chagas disease is an important vector-borne disease problem in South America, especially in rural areas where inhabitants are in contact with the reduviid insects that transmit the parasite Trypanosoma cruzi. Today, the main means of interrupting transmission of T. cruzi is to control the v ... more
Springer Nature published its first machine-generated book, compiled using an algorithm developed by researchers from Goethe University. This collaboration broke new ground with the first machine-generated book to be published by a scholarly publisher.
The book is available as a free downl ... more
Inflatable toys and swimming aids, like bathing rings and arm bands, often have a distinctive smell which could indicate that they contain a range of potentially hazardous substances. Some of these compounds, which include carbonyl compounds, cyclohexanone, phenol and isophorone, might be c ... more
Graphene, the one-atom-thick material made of carbon atoms, still holds some unexplained qualities, which are important in connection with electronic applications where high-conductivity matters, ranging from smart materials that collectively respond to external stimuli in a coherent, tunab ... more