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From Natural to Bioassisted and Biomimetic Artificial Water Channel Systems

Within biological systems, natural channels and pores transport metabolites across the cell membranes. Researchers have explored artificial ion-channel architectures as potential mimics of natural ionic conduction. All these synthetic systems have produced an impressive collection of alternative artificial ion-channels.Amazingly, researchers have made far less progress in the area of synthetic water channels. The development of synthetic biomimetic water channels and pores could contribute to a better understanding of the natural function of protein channels and could offer new strategies to generate highly selective, advanced water purification systems. Despite the imaginative work by synthetic chemists to produce sophisticated architectures that confine water clusters, most synthetic water channels have used natural proteins channels as the selectivity components, embedded in the diverse arrays of bioassisted artificial systems. These systems combine natural proteins that present high water conductance ...

Authors:   Mihail Barboiu; Arnaud Gilles
Journal:   Accounts of Chemical Research
Year:   2013
DOI:   10.1021/ar400025e
Publication date:   08-Apr-2013
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