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Application of peptide nucleic acid towards development of Nanobiosensor arrays

Peptide nucleic acid (PNA) is the modified DNA or DNA analog with neutral peptide backbone instead of a negatively charged sugar phosphate. PNA exhibits chemical stability, resistant to enzymatic degradation inside living cell, recognizing specific sequences of nucleic acid, formation of stable hybrid complexes like PNA/DNA/PNA triplex, strand invasion, extraordinary thermal stability and ionic strength, and unique hybridization relative to nucleic acids. These unique physicobiochemical properties of PNA enable new mode of detection, which is faster and more reliable analytical processes and finds applications in the molecular diagnostics & pharmaceutical fields. Besides, a variety of unique characteristic features, PNAs replace...

Authors:   Ravindra P., Singh , Byung-Keun, Oh , Jeong-Woo, Choi
Journal:   Bioelectrochemistry
Year:   2010
DOI:   10.1016/j.bioelechem.2010.02.004
Publication date:   02-Mar-2010
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