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Electrochemistry of interaction of 2-(2-nitrophenyl)-benzimidazole derivatives with DNA

In this study the interaction between new benzimidazole molecules, 2-(2-nitrophenyl)-1H-benzimidazole (NB) and N-benzoyl-2-(2-nitrophenyl)-benzimidazole (BNB), with dsDNA and ssDNA was assessed at pH 7.4. Using differential pulse voltammetry at glassy carbon electrode, both molecules were electrochemically reduced due to the presence of a nitro group in their structures. When DNA was added to the solution, the electrochemical signal of NB and BNB decreased and shifted to more negative potentials. The interaction mode was electrostatic when ionic strength was low. Under this condition DNA-nitro complexes were characterized and binding constants values of 8.22×104 M-1 and 3.08×106 M- 1 for NB and BNB...

Authors:   Mabel, Catalán , Alejandro, Álvarez-Lueje , Soledad, Bollo
Journal:   Bioelectrochemistry
Year:   2010
DOI:   10.1016/j.bioelechem.2010.02.002
Publication date:   19-Feb-2010
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