My watch list
my.chemeurope.com  
Login  

The endogenous GABA bioactivity of camel, bovine, goat and human milks

Publication date:

15 February 2014


Source:Food Chemistry, Volume 145

Author(s): Agenor Limon , Jose-Luis Gallegos-Perez , Jorge M. Reyes-Ruiz , Mohammad A. Aljohi , Ali S. Alshanqeeti , Ricardo Miledi

GABA orally administered has several beneficial effects on health, including the regulation of hyperglycaemic states in humans. Those effects are similar to the effects reported for camel milk (CMk); however, it is not known whether compounds with GABAergic activity are present in milk from camels or other species. We determined CMk free-GABA concentration by LS/MS and its bioactivity on human GABA receptors. We found that camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able to activate GABAρ receptors. The relationship between GABA and taurine concentrations suggests that whole camel milk may be more efficient to activate GABAρ1 receptors than goat milk. Because GABAρ receptors are normally found in enteroendocrine cells in the lumen of the digestive tract, these results suggest that GABA in camel and goat milk may participate in GABA-modulated functions of enteroendocrine cells in the GI lumen.





Authors:   Author(s): Agenor Limon , Jose-Luis Gallegos-Perez , Jorge M. Reyes-Ruiz , Mohammad A. Aljohi , Ali S. Alshanqeeti , Ricardo Miledi
Journal:   Food Chemistry
Year:   2013
Publication date:   23-Sep-2013
Facts, background information, dossiers
  • ALIS
More about Elsevier
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE