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Background: Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the psychoactive component of cannabis, is highly desirable for roadside testing. Results: A screen printed carbon electrode is used for the N-(4-amino-3-methoxyphenyl)-methanesulfonamide mediated detection of Δ 9 -THC in saliva. Mediator placed in an overlayer was galvanostatically oxidized and reacted with Δ 9 -THC to give an electrochemically active adduct which could be detected by chronoamperometric reduction. Detection of 25-50 ng/mL Δ 9 -THC spiked into undiluted saliva was achieved with a response time of 30 s. A trial of the sensors with four cannabis smokers showed sensitivity of 28 %, specificity of 99 % and accuracy of 52 %. Conclusions: Rapid electrochemical detection of Δ 9 -THC in undiluted saliva has been demonstrated using a disposable sensor, however the sensitivity is lower than acceptable. Further optimization of the assay and sensor format is required to improve the sensitivity of response to Δ 9 -THC.
| Authors: | Wanklyn, Ceri; Burton, Dan; Enston, Emma; Bartlett, Carrie-Ann; Taylor, Sarah; Raniczkowska, Aleksandra; Black, Murdo; Murphy, Lindy | |
| Journal: | Chemistry Central Journal | |
| Volume: | ${item.volume} | |
| edition: | 1 | |
| Year: | 2016 | |
| Pages: | 1 | |
| DOI: | 10.1186/s13065-016-0148-1 | |
| Publication date: | 21-Jan-2016 |
Background: Hydrazones and their metal complexes were heavily studied due to their pharmacological applications such as antimicrobial, anticonvulsant analgesic, anti-inflammatory and anti-cancer agents. This work aims to synthesize and characterize novel complexes of VO ... more
Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian cou ... more
Thermodynamic properties of 5(nitrophenyl) furan-2-carbaldehyde isomers
Background: The aim of the current work was to determine thermo dynamical properties of 5(2-nitro phenyl)-furan-2-carbaldehyde, 5(3-nitro phenyl)-furan-2-carbaldehyde and 5(4-nitro phenyl)-furan-2-carbaldehyde. Results: The temperature dependence of saturated vapor pressure of 5(2-nitro phe ... more
Both legitimate brewers and distillers - and authorities on the track of illicit alcohol from home stills - will soon have a helping hand. Measurement experts have unveiled a portable device to determine the strength of alcoholic drinks quickly and easily, almost anywhere. Published in the ... more
Reject watermelons -- the newest renewable energy source
Watermelon juice can be a valuable source of biofuel. Researchers writing in BioMed Central's open access journal Biotechnology for Biofuels have shown that the juice of reject watermelons can be efficiently fermented into ethanol. Wayne Fish worked with a team of researchers at the USDA-A ... more
The popular insect repellent deet is neurotoxic
The active ingredient in many insect repellents, deet, has been found to be toxic to the central nervous system. Researchers writing in BMC Biology say that more investigations are urgently needed to confirm or dismiss any potential neurotoxicity to humans, especially when deet-based repell ... more
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