Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva
Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ
-THC), the psychoactive component of cannabis, is highly desirable for roadside testing.
A screen printed carbon electrode is used for the N-(4-amino-3-methoxyphenyl)-methanesulfonamide mediated detection of Δ
-THC in saliva. Mediator placed in an overlayer was galvanostatically oxidized and reacted with Δ
-THC to give an electrochemically active adduct which could be detected by chronoamperometric reduction. Detection of 25-50 ng/mL Δ
-THC spiked into undiluted saliva was achieved with a response time of 30 s. A trial of the sensors with four cannabis smokers showed sensitivity of 28 %, specificity of 99 % and accuracy of 52 %.
Rapid electrochemical detection of Δ
-THC in undiluted saliva has been demonstrated using a disposable sensor, however the sensitivity is lower than acceptable. Further optimization of the assay and sensor format is required to improve the sensitivity of response to Δ
Hydrazones and their metal
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Wayne Fish worked with a team of researchers at the USDA-A ... more
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