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Development of a Two‐Photon Fluorescent Probe for Imaging of Endogenous Formaldehyde in Living Tissues

Abstract

Investigation of the physiological and pathological functions of formaldehyde (FA) are largely restricted by a lack of useful FA imaging agents, in particular, those that allow detection of FA in the context of living tissues. Herein, we present the rational design, synthesis, and photophysical property studies of the first two‐photon fluorescent FA probe, Na‐FA. Importantly, the highly desirable attributes of the probe Na‐FA (such as a very large turn‐on signal (up to 900‐fold), a low detection limit, and a very fast onset imparted by the unique design aspects of the probe), make it possible to monitor endogenous FA in living tissues for the first time. Furthermore, sodium bisulfite was identified as a simple and convenient inhibitor of FA within biological environments.

Formaldehyd im Rampenlicht: Die erste Zwei‐Photonen‐Fluoreszenzsonde für Formaldehyd (FA), Na‐FA, beruht auf der Kondensation einer Hydrazineinheit mit FA. Diese Strategie verleiht der Sonde sehr vorteilhafte Eigenschaften: ein sehr starkes Turn‐on‐Signal, eine niedrige Detektionsgrenze und eine sehr schnelle Detektion, was zusammen erstmals die Verfolgung von endogenem FA in lebendem Gewebe ermöglicht.

Authors:   Yonghe Tang, Xiuqi Kong, An Xu, Baoli Dong, Weiying Lin
Journal:   Angewandte Chemie
Year:   2016
Pages:   n/a
DOI:   10.1002/ange.201510373
Publication date:   04-Feb-2016
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