My watch list  

Development of a Two‐Photon Fluorescent Probe for Imaging of Endogenous Formaldehyde in Living Tissues


Investigation of the physiological and pathological functions of formaldehyde (FA) are largely restricted by a lack of useful FA imaging agents, in particular, those that allow detection of FA in the context of living tissues. Herein, we present the rational design, synthesis, and photophysical property studies of the first two‐photon fluorescent FA probe, Na‐FA. Importantly, the highly desirable attributes of the probe Na‐FA (such as a very large turn‐on signal (up to 900‐fold), a low detection limit, and a very fast onset imparted by the unique design aspects of the probe), make it possible to monitor endogenous FA in living tissues for the first time. Furthermore, sodium bisulfite was identified as a simple and convenient inhibitor of FA within biological environments.

Formaldehyd im Rampenlicht: Die erste Zwei‐Photonen‐Fluoreszenzsonde für Formaldehyd (FA), Na‐FA, beruht auf der Kondensation einer Hydrazineinheit mit FA. Diese Strategie verleiht der Sonde sehr vorteilhafte Eigenschaften: ein sehr starkes Turn‐on‐Signal, eine niedrige Detektionsgrenze und eine sehr schnelle Detektion, was zusammen erstmals die Verfolgung von endogenem FA in lebendem Gewebe ermöglicht.

Authors:   Yonghe Tang, Xiuqi Kong, An Xu, Baoli Dong, Weiying Lin
Journal:   Angewandte Chemie
Year:   2016
Pages:   n/a
DOI:   10.1002/ange.201510373
Publication date:   04-Feb-2016
More about Angewandte Chemie
  • News

    Fuel from a Greenhouse Gas

    One step toward carbon dioxide (CO2) neutrality and the mitigation of both the greenhouse effect and the energy crisis would be to convert CO2 into hydrocarbon-based fuels like methane using light. In the journal Angewandte Chemie, a Chinese research team has introduced a highly effective p ... more

    Economical PEF Production

    One possible replacement for drink containers made from PET is polyethylene furandicarboxylate (PEF), made from renewable resources. However, the production of the raw material for PEF from biomass is still rather inefficient. A new titanium-based photocatalyst could be about to change this ... more

    Cage with Caps: Selective confinement of rare-earth-metal hydrates in host molecules

    Rare-earth metals are indispensable for many technical products, from smartphones, laptops, batteries, electromotors, and wind turbines, to catalysts. In the journal Angewandte Chemie, a Japanese team has now introduced a molecular “cage” with “caps” that can be used to selectively “confine ... more

More about Wiley
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE