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Exploiting Cosolubilization of Warfarin, Curcumin and Rhodamine B for Modulation of Energy Transfer‐ A micelle FRET "On/Off" switch

Here in we introduce two new FRET pairs comprising of Warfarin, Curcumin, and Rhodamine B using surfactant based self‐assembled soft systems as scaffolds. Extension of the study was made to design a two‐step concurrent FRET system based on such three fluorophores, an important mechanism to devise artificial light harvesting/antenna systems. Surfactant systems of varying nature (cationic, anionic, nonionic, and zwitterionic) were exploited to modulate the energy transfer in different FRET systems. Interestingly a micelle‐water interfacial charge responsive FRET was observed owing to selective solubilization of the fluorophores during cosolubiization.The step one FRET (Warfarin to Curcumin) is switched 'on' in cationic and zwitterionic medium but switched 'off' in anionic/nonionic media while the step two FRET from Curcumin to Rhdamine B is switched 'on' in anionic/nonionic, and zwitterionic media. However, both the FRET steps (Warfarin→Curcumin→Rhodamine B) were observed to be active only in zwitterionic medium. Cosolubilization of appropriately mixed fluorophore having multistep FRET possibilities can be put 'on/off' selectively as and when required, with energy efficiency tuned to optimal level by varying nature and geometry of micellar scaffold.Thus the two FRET pairs selectively acknowledge all types of media for their anticipated applications in biological systems, as structural tools, development of artificial light harvesting/antenna systems and lasers.

Authors:   Parvaiz Ahmad Bhat, Oyais Ahmad Chat, Aijaz Ahmad Dar
Journal:   ChemPhysChem
Year:   2016
Pages:   n/a
DOI:   10.1002/cphc.201600274
Publication date:   28-Apr-2016
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