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526 Newest Publications from the industry laborausstattung / laborbedarf
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25-May-2018 | Masahide Kokado; Masayasu Miyajima; Yuka Okada; Kana Ichikawa; Osamu Yamanaka; Chia-Yang Liu; Winston Whei-Yang Kao; ..., Laboratory Investigation, 2018
We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ...
25-May-2018 | Masahide Kokado; Masayasu Miyajima; Yuka Okada; Kana Ichikawa; Osamu Yamanaka; Chia-Yang Liu; Winston Whei-Yang Kao; ..., Laboratory Investigation, 2018
We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ...
23-May-2018 | Jessica Davis-Knowlton; Jacqueline E. Turner; Anna Turner; Sydney Damian-Loring; Nicholas Hagler; Terry Henderson; I ..., Laboratory Investigation, 2018
Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that contributes to atherosclerosis. Further understanding of this degenerative process in humans will require human tissue. Plaque removed ...
22-May-2018 | Jian Xu; Jingjing Wang; Mengyu He; Honghao Han; Weiping Xie; Hong Wang; Hui Kong, Laboratory Investigation, 2018
Dipeptidyl peptidase IV (DPP-4) is well known for its role in glucose homeostasis, and DPP-4 inhibitor (DPP-4i) exhibits multiple actionsin cardiovascular diseases. However, the effect of DPP-4i on pulmonary hypertension (PH) remains unclear. Therefore, this study aims to investigate the effect ...
22-May-2018 | Shasha Hou; Ying Jiao; Qi Yuan; Junfeng Zhai; Tian Tian; Kaiji Sun; Zhinan Chen; Zhenlong Wu; Jinhua Zhang, Laboratory Investigation, 2018
As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the ...
22-May-2018 | Yueh-Hua Chung; Ying-Hsien Huang; Tien-Huei Chu; Chun-Lin Chen; Pey-Ru Lin; Shih-Chung Huang; Deng-Chyang Wu; Chao-C ..., Laboratory Investigation, 2018
Transforming growth factor-β (TGF-β) plays a central role in hepatic fibrogenesis. This study investigated the function and mechanism of bone morphogenetic protein-2 (BMP-2) in regulation of hepatic fibrogenesis. BMP-2 expression in fibrotic liver was measured in human tissue microarray and mouse ...
21-May-2018 | Yonglun Kong; Qingchun Liang; Yanting Chen; Pingzhen Yang; Xiaoyu Liu; Yining Li; Siyuan Feng; Ji Wu; Wantao Liu; Ji ..., Laboratory Investigation, 2018
Vascular calcification is a highly regulated biological process similar to bone formation involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan (HA), a major structural component of the extracellular matrix in cartilage, has been shown to inhibit osteoblast ...
21-May-2018 | Youngin Kwon; Soo-Kyoung Choi; Seonhee Byeon; Young-Ho Lee, Laboratory Investigation, 2018
Inhibitor kappa B kinase 2 (IKK2) plays an essential role in the activation of nuclear factor kappa B (NF-kB). Recently, it has been suggested that IKK2 acts as a myosin light chain kinase (MLCK) and contributes to vasoconstriction in mouse aorta. However, the underlying mechanisms are still ...
21-May-2018 | Hui-Ta Wu; Cheng-Rong Xie; Jie Lv; He-Qiang Qi; Fei Wang; Sheng Zhang; Qin-Liang Fang; Fu-Qiang Wang; Yu-Yan Lu; Zhe ..., Laboratory Investigation, 2018
Downregulation of deleted in liver cancer 1 (DLC1) is associated with poor prognosis of various cancers, but its functional mechanisms in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the roles of DLC1 in tumor progression and autophagy of HCC. We found ...
16-May-2018 | Francesco Cucco; Alexandra Clipson; Hannah Kennedy; Joe Sneath Thompson; Ming Wang; Sharon Barrans; Moniek van Hoppe ..., Laboratory Investigation, 2018
DNA samples from formalin-fixed paraffin-embedded tissues are highly degraded with variable quality, and this imposes a big challenge for targeted sequencing due to false positives, largely caused by PCR errors and cytosine deamination. To eliminate false positives, a common practice is to ...