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Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation

16-May-2018 | Yim Ling Yip; Weitao Lin; Wen Deng; Lin Jia; Kwok Wai Lo; Pierre Busson; Benjamin Vérillaud; Xuefeng Liu; Chi M ..., Laboratory Investigation, 2018

Epstein–Barr virus (EBV) infects more than 90% of the adult human population. Undifferentiated nasopharyngeal carcinoma (NPC) is common in Southeast Asia, with a particularly high incidence among southern Chinese. The EBV genome can be detected in practically all cancer cells in undifferentiated ...


Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study

15-May-2018 | Cong Chen; Zhi-cheng He; Yu Shi; Wenchao Zhou; Xia Zhang; Hua-liang Xiao; Hai-bo Wu; Xiao-hong Yao; Wan-chun Luo; Yo ..., Laboratory Investigation, 2018

The microvascular profile has been included in the WHO glioma grading criteria. Nevertheless, microvessels in gliomas of the same WHO grade, e.g., WHO IV glioblastoma (GBM), exhibit heterogeneous and polymorphic morphology, whose possible clinical significance remains to be determined. In this ...


Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice

15-May-2018 | Yuefei Jin; Chao Zhang; Hui Wang; Guangyuan Zhou; Xiangpeng Wang; Rongguang Zhang; Shuaiyin Chen; Jingchao Ren; Lu C ..., Laboratory Investigation, 2018

Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with ...


Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice

10-May-2018 | Joseph George; Irene K. Yan; Tushar Patel, Laboratory Investigation, 2018

Hepatocellular carcinoma is highly resistant to chemotherapy. Here we evaluated the use and efficacy of milk-derived nanovesicles (MNV) as an approach to improve delivery of anticancer agents into HCC cells and intrahepatic tumors. We developed a protocol for isolation of MNVs from skim milk ...


Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

10-May-2018 | Alvin Ho-Kwan Cheung; Chit Chow; Jinglin Zhang; Yuhang Zhou; Tingting Huang; Kayla Ching-Kei Ng; Terry Cho-Tsun Or; ..., Laboratory Investigation, 2018

Cancer cells are defined genetically by the mutations they harbor, commonly single nucleotide substitutions. Therapeutic approaches which specifically target cancer cells by recognizing these defining genetic aberrations are expected to exhibit minimal side-effects. However, current protein-based ...


Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium

09-May-2018 | Werner Boecker; Laura Horn; Göran Stenman; Christine Stürken; Udo Schumacher; Thomas Loening; Lukas Liesen ..., Laboratory Investigation, 2018

Understanding the mechanisms regulating human mammary epithelium requires knowledge of the cellular constituents of this tissue. Different and partially contradictory definitions and concepts describing the cellular hierarchy of mammary epithelium have been proposed, including our studies of ...


Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA, and protein analyses

27-Mar-2018 | David Svec; Soheila Dolatabadi; Christer Thomsen; Nicole Cordes; Mark Shannon; Paul Fitzpatrick; Göran Landberg ..., Laboratory Investigation, 2018

FUS-DDIT3 belongs to the FET (FUS, EWSR1, and TAF15) family of fusion oncogenes, which collectively are considered to be key players in tumor development. Even though over 90% of all myxoid liposarcomas (MLS) have a FUS-DDIT3 gene fusion, there is limited understanding of the signaling pathways ...


Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death

26-Mar-2018 | Li Gao; Ming-Ming Liu; Hong-mei Zang; Qiu-Ying Ma; Qin Yang; Ling Jiang; Gui-Ling Ren; Hai-Di Li; Wei-Feng Wu; Jia-n ..., Laboratory Investigation, 2018

E-cadherin is a major component of tubular adherent proteins that maintain intercellular contacts and cell polarity in epithelial tissue. It is involved in pathological processes of renal cell carcinoma and fibrotic diseases via epithelial–mesenchymal transition. Although studies have shown ...


Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis

26-Mar-2018 | Hisashi Yoshimura; Yoko Matsuda; Masami Yamamoto; Masaki Michishita; Kimimasa Takahashi; Norihiko Sasaki; Naoshi Ish ..., Laboratory Investigation, 2018

H19 is an oncofetal RNA expressed in the developing embryo as well as in bladder, breast, gastric, pancreatic, hepatocellular, and prostate cancers. Recent studies have shown that H19 enhances cancer invasion and metastasis; however, its roles in cancer remain controversial. In the current study, ...


Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial–mesenchymal transition

26-Mar-2018 | Tianwen Lai; Yanyu Li; Min Chen; Guihai Pan; Xiaoxia Wen; Zongjiong Mai; Yalian Yuan; Yingying Lv; Quanchao Lv; Ruil ..., Laboratory Investigation, 2018

Although airway fibrosis and epithelial–mesenchymal transition (EMT) contribute to airway remodeling in chronic obstructive pulmonary disease (COPD), the mechanisms underlying their development have not been fully elucidated. In the present study, we aimed to assess heparin-binding epidermal ...


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