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Rapid “turn-on” photoluminescence detection of bisulfite in wines and living cells with formyl bearing bis-cyclometalated Ir(III) complex

20-Jun-2018 | Hongfang Gao; Hetong Qi; Yijin Peng; Honglan Qi; Chengxiao Zhang, Analyst, 2018

A new photoluminescence (PL) probe based on formyl bearing bis-cyclometalated Ir(III) complex, [Ir(ppy)2phen-CHO]+PF6- (1), is synthesized and applied to selective detection of bisulfite anion (HSO3-). The probe 1 is prepared by using 2-phenylpyridine (ppy) as C^N main ligand and ...


Direct Label-Free Imaging of Brain Tissue using Synchrotron Light: A Review of New Spectroscopic Tools for the Modern Neuroscientist

20-Jun-2018 | M. Jake Pushie; Michael E Kelly; Mark Hackett, Analyst, 2018

The incidence of brain disease and brain disorders is increasing on a global scale. Unfortunately, development of new therapeutic strategies has not increased at the same rate, and brain diseases and brain disorders now inflict substantial health and economic impacts. A greater understanding of ...


Optical Assays Based on Colloidal Inorganic Nanoparticles

20-Jun-2018 | Amir Ghasemi; Navid Rabiee; Sepideh Ahmadi; shabnam hashemzadeh; Farshad Lolasi; Mashnaz Borzogomid; Alireza Kalbas ..., Analyst, 2018

Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20-nm diameter size range) to undergo a color change from red to blue upon aggregation. AuNP ...


Highly sensitive detection of nucleic acids using cascade amplification strategy based on exonuclease III-assisted target recycling and conjugated polyelectrolytes

20-Jun-2018 | Biqing Bao; Yanrui Pan; Binbin Gu; Jia Chen; Yu Xu; Peng Su; Yunfei Liu; Li Tong; Lian-Hui Wang, Analyst, 2018

In this paper, a novel ratiometric and cascade amplification strategy was developed by combing the unique signal amplification and effecitive fluorescence resonance energy transfer (FRET) property of conjugated polymers with Exo III-assisted target recycling method. The target DNA (ssDNAc) could ...


Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury

20-Jun-2018 | Gyaninder Pal Singh; Richa Nigam; Gaurav Singh Tomar; Mohan Monisha; Sanjeev Kumar Bhoi; Arulselvi S; Kangana Sengar ..., Analyst, 2018

The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all ...


Investigating the Autophagic Pathway in Silver@Gold Core Shell Nanoparticles-Treated Cells Using Surface-Enhanced Raman Scattering

20-Jun-2018 | Yuqing Hou; Wen Zhang; Sheng tao Li; Zhen Wang; Huiqing Zhong; Zhiming Liu; Zhouyi Guo, Analyst, 2018

Previous studies have shown that nanoparticles can induce autophagy, and the main approach for investigating autophagy induced by nanoparticles is through traditional methods such as TEM and biochemical assay. These measurements suffer from the problems of complicated experimental processes or ...


Multi-Functional Derivatization of Amine, Hydroxyl, and Carboxylate Groups for Metabolomic Investigations of Human Tissue by Electrospray Ionization Mass Spectrometry

20-Jun-2018 | Tianjiao Huang; Maria Toro-Moreno; Dawn S Hui; Richard Lee; James L Edwards, Analyst, 2018

Metabolomics, the study of small molecules involved in cellular processes, offers the potential to reveal insights into the pathophysiology of disease states. Analysis of metabolites by electrospray mass spectrometry is complicated by their structural diversity. Amine, hydroxyl, and carboxylate ...


Label-Free Tracking of Nanosized Graphene Oxide Cellular Uptake by Confocal Raman Microscopy

20-Jun-2018 | Marianna Eliášová Sohová; Michal Bodik; Peter Siffalovic; Nikola Bugarova; Martina Labudová; Mir ..., Analyst, 2018

Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy. The nanometer-sized GO is known to permeate the cell membrane. Herein we studied the cellular uptake pathways of GO nanoflakes by cancer and ...


Single-system based discriminative optical sensors: Different strategies and versatile applications

20-Jun-2018 | Junmei Fan; Liping Ding, Analyst, 2018

Discriminative optical sensors with pattern recognition property and high-throughput ability have been widely developed as they can distinguish multiple chemically similar analytes. Compared to traditional sensor arrays composed of a series of sensor elements, single-system based discriminative ...


A pyrene -involved luminescent MOF for monitoring 1-Hyroxypyrene, a biomarker for human intoxication of PAH carcinogens

20-Jun-2018 | You Zhou; Qian Yang; Jing Cuan; Yanan Wang; Ning Gan; Yuting Cao; Tianhua Li, Analyst, 2018

1-hydroxypyrene (1-HP) is a urinary metabolite of polycyclic aromatic hydrocarbons (PAHs), and can function as a convenient biomarker for human intoxication of PAH carcinogens. The development of simple 1-HP sensors with high sensitivity and fast response is highly desirable. Herein, we ...


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