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10,435 Newest Publications in analytical chemistry

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Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin

17-Jan-2018 | Zijuan Hai; Jingjing Wu; Dilizhatai Saimi; Yanhan Ni; Rongbin Zhou; Gaolin Liang, Analytical Chemistry, 2018

Development of sensitive fluorescence “Turn-On” strategies for imaging enzyme activity in living cells is of disease-diagnostic importance but remains challenging. Herein, by employing a click condensation reaction and rational design of a single quenched probe ...

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Methodology for the Validation of Isotopic Analyses by Mass Spectrometry in Stable-Isotope Labeling Experiments

17-Jan-2018 | Maud Heuillet; Floriant Bellvert; Edern Cahoreau; Fabien Letisse; Pierre Millard; Jean-Charles Portais, Analytical Chemistry, 2018

Stable-isotope labeling experiments (ILEs) are widely used to investigate the topology and operation of metabolic networks. The quality of isotopic data collected in ILEs is of utmost importance to ensure reliable biological interpretations, but current evaluation approaches are limited due to a ...

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A Rapid Method for Antigen-Specific Hybridoma Clone Isolation

17-Jan-2018 | Xiuqing Li; Hongfen Bian; Siming Yu; Wei Xiao; Jianying Shen; Caifeng Lan; Kenan Zhou; Caihong Huang; Lei Wang; Dan ..., Analytical Chemistry, 2018

Using an enzyme-linked immunosorbent assay (ELISA) and limited dilution methods to screen and clone antigen-specific hybridoma cells is extremely time-consuming and labor-intensive. This work features a simple and rapid cell surface fluorescence immunosorbent assay (CSFIA), designed for the ...

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Application of Electrochemical Devices to Characterize the Dynamic Actions of Helicases on DNA

17-Jan-2018 | Dimithree Kahanda; Kevin T. DuPrez; Eduardo Hilario; Marc A. McWilliams; Chris H. Wohlgamuth; Li Fan; Jason D. Slinker, Analytical Chemistry, 2018

Much remains to be understood about the kinetics and thermodynamics of DNA helicase binding and activity. Here, we utilize probe-modified DNA monolayers on multiplexed gold electrodes as a sensitive recognition element and morphologically responsive transducer of helicase–DNA interactions. The ...

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LipSpin: A New Bioinformatics Tool for Quantitative 1H NMR Lipid Profiling

17-Jan-2018 | Rubén Barrilero; Miriam Gil; Núria Amigó; Cintia B. Dias; Lisa G. Wood; Manohar L. Garg; Josep Ribalta; Mercedes Her ..., Analytical Chemistry, 2018

The structural similarity among lipid species and the low sensitivity and spectral resolution of nuclear magnetic resonance (NMR) have traditionally hampered the routine use of 1H NMR lipid profiling of complex biological samples in metabolomics, which remains mostly manual and lacks freely ...

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Insights into the MALDI Process after Matrix Deposition by Sublimation Using 3D ToF-SIMS Imaging

17-Jan-2018 | Sebastiaan Van Nuffel; Nicolas Elie; Ethan Yang; Julius Nouet; David Touboul; Pierre Chaurand; Alain Brunelle, Analytical Chemistry, 2018

Imaging mass spectrometry (IMS) has become a powerful tool to characterize the spatial distribution of biomolecules in thin tissue sections. In the case of matrix-assisted laser desorption ionization (MALDI) IMS, homogeneous matrix deposition is critical to produce high-quality ion images, and ...

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Correction for the Hematocrit Bias in Dried Blood Spot Analysis Using a Nondestructive, Single-Wavelength Reflectance-Based Hematocrit Prediction Method

17-Jan-2018 | Sara Capiau; Leah S. Wilk; Pieter M. M. De Kesel; Maurice C. G. Aalders; Christophe P. Stove, Analytical Chemistry, 2018

The hematocrit (Hct) effect is one of the most important hurdles currently preventing more widespread implementation of quantitative dried blood spot (DBS) analysis in a routine context. Indeed, the Hct may affect both the accuracy of DBS methods as well as the interpretation of DBS-based ...

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Facile Synthesis of Gadolinium Chelate-Conjugated Polymer Nanoparticles for Fluorescence/Magnetic Resonance Dual-Modal Imaging

17-Jan-2018 | Yi Pan; Wandi Chen; Jun Yang; Junhui Zheng; Mengsu Yang; Changqing Yi, Analytical Chemistry, 2018

Fluorescence (FL)/magnetic resonance (MR) dual-modal imaging nanoprobes are significant not only for cutting edge research in molecular imaging, but also for clinical diagnosis with high precision and accuracy. However, synthesis of FL/MR dual-modal imaging nanoprobes that simultaneously exhibit ...

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Water-Resistant Polymeric Acid Membrane Catalyst for Acetone Detection in the Exhaled Breath of Diabetics

17-Jan-2018 | Adam D. Worrall; Zexin Qian; Jonathan A. Bernstein; Anastasios P. Angelopoulos, Analytical Chemistry, 2018

Endogenous volatile organic compounds (VOCs) such as acetone in exhaled human breath are associated with metabolic conditions in the bloodstream. Development of compact, rapid detectors of exhaled breath chemical composition in clinical settings is challenging due to the small sample size that ...

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Design of a Single-Layer Microchannel for Continuous Sheathless Single-Stream Particle Inertial Focusing

17-Jan-2018 | Yan Zhang; Jun Zhang; Fei Tang; Weihua Li; Xiaohao Wang, Analytical Chemistry, 2018

High-throughput, high-precision single-stream focusing of microparticles has a potentially wide range of applications in biochemical analysis and clinical diagnosis. In this work, we develop a sheathless three-dimensional (3D) particle-focusing method in a single-layer microchannel. This novel ...

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