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1,838 Newest Publications in annals of the new york academy of sciences

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Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia

01-Apr-2010 | Adorini, Luciano; Penna, Giuseppe; Fibbi, Benedetta; Maggi, Mario, Annals of the New York Academy of Sciences, 2010

The bioactive form of vitamin D, 1,25-dihydroxyvitamin D3, is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions. The VDR is expressed by most cell types, including cells of the urogenital ...

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Insulin resistance in rheumatoid arthritis: the impact of the anti‐TNF‐α therapy

01-Apr-2010 | Gonzalez‐Gay, Miguel A.; Gonzalez‐Juanatey, Carlos; Vazquez‐Rodriguez, Tomas R.; Miranda‐ ..., Annals of the New York Academy of Sciences, 2010

Increased prevalence of insulin resistance has been observed in patients with rheumatoid arthritis (RA). High-grade systemic inflammation is implicated in the development of insulin resistance in these patients. Tumor necrosis factor (TNF)-[alpha] is a potent proinflammatory cytokine that plays a ...

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Changes in adiponectin and leptin concentrations during glucocorticoid treatment: a pilot study in patients with polymyalgia rheumatica

01-Apr-2010 | Cimmino, M. A.; Andraghetti, G.; Briatore, L.; Salani, B.; Parodi, M.; Cutolo, M.; Cordera, R., Annals of the New York Academy of Sciences, 2010

This study is concerned with an evaluation of the effects of glucocorticoids (GC) on adiponectin and leptin concentrations in patients with polymyalgia rheumatica (PMR). Seven patients diagnosed with PMR were studied at baseline and after one and three months of prednisone treatment. Serum leptin ...

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The burden of comorbidity and the C‐reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis‐related cardiovascular complications

01-Apr-2010 | Martocchia, Antonio; Cola, Silvia; Frugoni, Patrizia; Indiano, Ilaria; D’Urso, Rosaria; Falaschi, Paolo, Annals of the New York Academy of Sciences, 2010

Thyroid hormones undergo significant modifications during severe illnesses, and the low T3 levels are the hallmark of nonthyoidal illness syndrome (NTIS), due to a reduced extrathyroidal conversion from T4. We examined 41 patients with NTIS by a modified cumulative illness rating scale (CIRS) and ...

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Cerebral lesions in patients with connective tissue diseases and systemic vasculitides: are there specific patterns?

01-Apr-2010 | Schedel, Joerg; Kuchenbuch, Sonja; Schoelmerich, Juergen; Feuerbach, Stefan; Geissler, Angela; Mueller‐Ladner ..., Annals of the New York Academy of Sciences, 2010

This study was performed to evaluate whether specific patterns of cerebral lesions can be identified in different rheumatic disease entities. In 132 patients with different connective tissue diseases and vasculitides (systemic lupus erythematosus [SLE], systemic sclerosis [SSc], mixed connective ...

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Psoriatic arthritis

01-Apr-2010 | Atzeni, Fabiola; Straub, Rainer H.; Cutolo, Maurizio; Sarzi‐Puttini, Piercarlo, Annals of the New York Academy of Sciences, 2010

In a chronic inflammatory disease, such as rheumatoid arthritis (RA), the hypothalamic-pituitary-adrenal axis is altered in three ways: (1) the inflammation-related spontaneous and stimulated secretion of cortisol is inadequate; (2) the inflammation-related secretion of adrenocorticotropic ...

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Anti‐TNF therapy restores the hypothalamic‐pituitary‐adrenal axis

01-Apr-2010 | Atzeni, Fabiola; Straub, Rainer H.; Cutolo, Maurizio; Sarzi‐Puttini, Piercarlo, Annals of the New York Academy of Sciences, 2010

Tumor necrosis factor (TNF) inhibitors are associated with greater improvements in the symptoms and signs of rheumatoid arthritis (RA) and, more importantly, a lower risk of joint damage. TNF is an important mediator of the alterations in neuroendocrine axes characterizing RA. Long-term therapy ...

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Neuroendocrine immunology of fibromyalgia

01-Apr-2010 | Di Franco, Manuela; Iannuccelli, Cristina; Valesini, Guido, Annals of the New York Academy of Sciences, 2010

The pathophysiology of fibromyalgia (FM) is not completely understood. The disease is characterized by a central sensitization with an amplification of pain perception. A combination of interactions among external stressors, behavioral constructs, neurotransmitters, hormones, immune, and ...

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