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1,760 Newest Publications in beilstein journal of organic chemistry

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Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

19-Jan-2018 | Masanori Inaba; Tatsuya Sakai; Shun Shinada; Tsuyuka Sugiishi; Yuta Nishina; Norio Shibata; Hideki Amii, Beilstein Journal of Organic Chemistry, 2018

Abstract Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and ...

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Progress in copper-catalyzed trifluoromethylation

17-Jan-2018 | Guan-bao Li; Chao Zhang; Chun Song; Yu-dao Ma, Beilstein Journal of Organic Chemistry, 2018

Abstract The introduction of trifluoromethyl groups into organic molecules has attracted great attention in the past five years. In this review, we describe the recent efforts in the development of trifluoromethylation via copper catalysis using nucleophilic, electrophilic or radical ...

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Gram-scale preparation of negative-type liquid crystals with a CF2CF2-carbocycle unit via an improved short-step synthetic protocol

15-Jan-2018 | Tatsuya Kumon; Shohei Hashishita; Takumi Kida; Shigeyuki Yamada; Takashi Ishihara; Tsutomu Konno, Beilstein Journal of Organic Chemistry, 2018

Abstract Herein, we demonstrate an improved short-step protocol for the synthesis of multicyclic molecules having a CF2CF2-containing cyclohexadiene or cyclohexane framework in a mesogenic structure. These molecules are promising candidates for vertical alignment (VA)-mode liquid crystal (LC) ...

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Volatiles from the tropical ascomycete Daldinia clavata (Hypoxylaceae, Xylariales)

12-Jan-2018 | Tao Wang; Kathrin I. Mohr; Marc Stadler; Jeroen S. Dickschat, Beilstein Journal of Organic Chemistry, 2018

Abstract The volatiles from the fungus Daldinia clavata were collected by use of a closed-loop stripping apparatus and analysed by GC–MS. A few compounds were readily identified by comparison of measured to library mass spectra and of retention indices to published data, while for other ...

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Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline

11-Jan-2018 | Benedikt C. Melzer; Jan G. Felber; Franz Bracher, Beilstein Journal of Organic Chemistry, 2018

Abstract Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required. Here we present a novel method for the introduction of a methyl group at C1 of isoquinolines. This is exemplified by ...

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Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

10-Jan-2018 | Mattias Bood; Sangamesh Sarangamath; Moa S. Wranne; Morten Grøtli; L. Marcus Wilhelmsson, Beilstein Journal of Organic Chemistry, 2018

Abstract Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base–base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic acid bases inside the base-stack, base ...

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Stereochemical outcomes of C–F activation reactions of benzyl fluoride

09-Jan-2018 | Neil S. Keddie; Pier Alexandre Champagne; Justine Desroches; Jean-François Paquin; David O'Hagan, Beilstein Journal of Organic Chemistry, 2018

Abstract In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds. Paquin’s group has reported extensive studies on the C–F activation of benzylic fluorides for ...

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Polarization spectroscopy methods in the determination of interactions of small molecules with nucleic acids – tutorial

08-Jan-2018 | Tamara Šmidlehner; Ivo Piantanida; Gennaro Pescitelli, Beilstein Journal of Organic Chemistry, 2018

Abstract The structural characterization of non-covalent complexes between nucleic acids and small molecules (ligands) is of a paramount significance to bioorganic research. Highly informative methods about nucleic acid/ligand complexes such as single crystal X-ray diffraction or NMR ...

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Photocatalytic formation of carbon–sulfur bonds

05-Jan-2018 | Alexander Wimmer; Burkhard König, Beilstein Journal of Organic Chemistry, 2018

Abstract This review summarizes recent developments in photocatalyzed carbon–sulfur bond formation. General concepts, synthetic strategies and the substrate scope of reactions yielding thiols, disulfides, sulfoxides, sulfones and other organosulfur compounds are discussed together with the ...

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Aminosugar-based immunomodulator lipid A: synthetic approaches

04-Jan-2018 | Alla Zamyatina, Beilstein Journal of Organic Chemistry, 2018

Abstract The immediate immune response to infection by Gram-negative bacteria depends on the structure of a lipopolysaccharide (LPS, also known as endotoxin), a complex glycolipid constituting the outer leaflet of the bacterial outer membrane. Recognition of picomolar quantities of pathogenic ...

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