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5,664 Newest Publications in biochemistry

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Proteomic Analysis of the Downstream Signaling Network of PARP1

19-Jan-2018 | Yuanli Zhen; Yonghao Yu, Biochemistry, 2018

Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is critically involved in many biological processes that are linked to cell stress responses. It is catalyzed by a class of enzymes known as poly-ADP-ribose polymerases (PARPs). In particular, PARP1 is a ...

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Mechanism and Structure of γ-Resorcylate Decarboxylase

19-Jan-2018 | Xiang Sheng; Yury Patskovsky; Anna Vladimirova; Jeffrey B. Bonanno; Steven C. Almo; Fahmi Himo; Frank M. Raushel, Biochemistry, 2018

γ-Resorcylate decarboxylase (γ-RSD) has evolved to catalyze the reversible decarboxylation of 2,6-dihydroxybenzoate to resorcinol in a nonoxidative fashion. This enzyme is of significant interest because of its potential for the production of γ-resorcylate and other benzoic acid derivatives under ...

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A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist

19-Jan-2018 | Gennaro Riccio; Sara Bottone; Giuseppe La Regina; Nadia Badolati; Sara Passacantilli; Giovanni Battista Rossi; Anton ..., Biochemistry, 2018

The WNT pathway interconnects a network of signaling events involved in a huge plethora of cellular processes, from organogenesis to tissue homeostasis. Despite its importance, the exiguity of organic drugs directly targeting the members of the Frizzled family of WNT receptors has hampered ...

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In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles

19-Jan-2018 | Boris Y. Zaslavsky; Vladimir N. Uversky, Biochemistry, 2018

Despite the common practice of presenting structures of biological molecules on an empty background and the assumption that interactions between biological macromolecules take place within the inert solvent, water represents an active component of various biological processes. This Perspective ...

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Microbiota-Regulated Outcomes of Human Cancer Immunotherapy via the PD-1/PD-L1 Axis

19-Jan-2018 | Jaymin Patel; Jason M. Crawford, Biochemistry, 2018

Biochemistry DOI: 10.1021/acs.biochem.7b01249

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Design of a “Mini” Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1

19-Jan-2018 | Wei-Che Hsieh; Raman Bahal; Shivaji A. Thadke; Kirti Bhatt; Krzysztof Sobczak; Charles Thornton; Danith H. Ly, Biochemistry, 2018

Toxic RNAs containing expanded trinucleotide repeats are the cause of many neuromuscular disorders, one being myotonic dystrophy type 1 (DM1). DM1 is triggered by CTG-repeat expansion in the 3′-untranslated region of the DMPK gene, resulting in a toxic gain of RNA function through sequestration ...

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A (Re)Discovery of the Fom3 Substrate

18-Jan-2018 | Anthony J. Blaszczyk; Squire J. Booker, Biochemistry, 2018

Biochemistry DOI: 10.1021/acs.biochem.7b01281

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Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight

18-Jan-2018 | Keith D. Green; Tapan Biswas; Allan H. Pang; Melisa J. Willby; Matthew S. Reed; Olga Stuchlik; Jan Pohl; James E. Po ..., Biochemistry, 2018

Bacterial nucleoid-associated proteins (NAPs) are critical to genome integrity and chromosome maintenance. Post-translational modifications of bacterial NAPs appear to function similarly to their better studied mammalian counterparts. The histone-like NAP HupB from Mycobacterium tuberculosis ...

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A Structure-Based Assembly Screen of Protein Cage Libraries in Living Cells: Experimentally Repacking a Protein–Protein Interface To Recover Cage Formation in an Assembly-Frustrated Mutant

17-Jan-2018 | Thomas A. Cornell; Maziar S. Ardejani; Jing Fu; Stephanie H. Newland; Yu Zhang; Brendan P. Orner, Biochemistry, 2018

Cage proteins, which assemble into often highly symmetric hollow nanoscale capsules, have great potential in applications as far reaching as drug delivery, hybrid nanomaterial engineering, and catalysis. In addition, they are promising model systems for understanding how cellular nanostructures ...

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Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2

17-Jan-2018 | Derek F. Harris; Dmitriy A. Lukoyanov; Sudipta Shaw; Phil Compton; Monika Tokmina-Lukaszewska; Brian Bothner; Neil K ..., Biochemistry, 2018

Of the three forms of nitrogenase (Mo-nitrogenase, V-nitrogenase, and Fe-nitrogenase), Fe-nitrogenase has the poorest ratio of N2 reduction relative to H2 evolution. Recent work on the Mo-nitrogenase has revealed that reductive elimination of two bridging Fe–H–Fe hydrides on the active site ...

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