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234 Newest Publications in biological chemistry


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Promising approaches in using magnetic nanoparticles in oncology

06-Oct-2011 | Georgy Mikhaylov; Olga Vasiljeva, Biological Chemistry, 2011

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of ...


Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

06-Oct-2011 | Stefan Tholen; Martin L. Biniossek; Anna-Lena Geßler; Sebastian Müller; Juliane Weißer; Jayachan ..., Biological Chemistry, 2011

Abstract The endolysosomal cysteine endoprotease cathepsin L is secreted from cells in a variety of pathological conditions such as cancer and arthritis. We compared the secretome composition and extracellular proteolytic cleavage events in cell supernatants of cathepsin L-deficient and wild-type ...


The Nicastrin ectodomain adopts a highly thermostable structure

06-Oct-2011 | Regina Fluhrer; Frits Kamp; Gudula Grammer; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass, Biological Chemistry, 2011

Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins ...


The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9

06-Oct-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...


Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways

06-Oct-2011 | Larisa Ring; Iris Peröbner; Marisa Karow; Marianne Jochum; Peter Neth; Alexander Faussner, Biological Chemistry, 2011

Abstract WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four different signaling cascades. The ...


Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

06-Oct-2011 | Oliver Schilling; Ulrich auf dem Keller; Christopher M. Overall, Biological Chemistry, 2011

Abstract Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an ...


mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

06-Oct-2011 | Matthias Kotzsch; Julia Dorn; Kristina Doetzer; Barbara Schmalfeldt; Janna Krol; Gustavo Baretton; Marion Kie ..., Biological Chemistry, 2011

Abstract High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified ...


Highlight: The Winter School on Proteinases and Their Inhibitors

06-Oct-2011 | Christian P. Sommerhoff; Hans Fritz, Biological Chemistry, 2011

No abstract available


Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections

06-Sep-2011 | (Stephan Ludwig), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 837-847, October 2011.


Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats

06-Sep-2011 | (Nigel Irwin et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 909-918, October 2011.


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