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486 Newest Publications in chembiochem

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DNA Recognition by Synthetic Constructs

05-Sep-2011 | Elena Pazos; Jesús Mosquera; M. Eugenio Vázquez; José L. Mascareñas, ChemBioChem, 2011

Abstract The interaction of transcription factors with specific DNA sites is key for the regulation of gene expression. Despite the availability of a large body of structural data on protein–DNA complexes, we are still far from fully understanding the molecular and biophysical bases underlying ...

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Identifying Protein Variants with Cross‐Reactive Aptamer Arrays

05-Sep-2011 | Sara Stewart; Angel Syrett; Arti Pothukuchy; Sancheeta Bhadra; Andrew Ellington; Eric Anslyn, ChemBioChem, 2011

Sense and sensibility: Synthetic oligonucleotide receptors have been generated that are capable of discriminating proteins with as little as four amino acids substitutions. This leads to the possibility that a panel of cross‐reactive aptamers can be an effective tool for discriminating proteins ...

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Pmarg‐Pearlin is a Matrix Protein Involved in Nacre Framework Formation in the Pearl Oyster Pinctada margaritifera

05-Sep-2011 | C. Montagnani; B. Marie; F. Marin; C. Belliard; F. Riquet; A. Tayalé; I. Zanella‐Cléon; E. Fleury; Y. Gueguen; D. Pi ..., ChemBioChem, 2011

Abstract The shell of pearl oysters is organized in multiple layers of CaCO3 crystallites packed together in an organic matrix. Relationships between the components of the organic matrix and mechanisms of nacre formation currently constitute the main focus of research into biomineralization. In ...

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Fluorescence Properties of 8‐(2‐Pyridyl)guanine “2PyG” as Compared to 2‐Aminopurine in DNA

05-Sep-2011 | Anaëlle Dumas; Nathan W. Luedtke, ChemBioChem, 2011

Abstract Because of their environment‐sensitive fluorescence quantum yields, base analogues such as 2‐aminopurine (2AP), 6‐methylisoxanthopterin (6‐MI), and 3‐methylisoxanthopterin (3‐MI) are widely used in nucleic‐acid folding and catalysis assays. Emissions from these guanine mimics are ...

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Hot on the Trail of Trehalose: A Carbohydrate‐Based Method for Imaging Mycobacterium tuberculosis

05-Sep-2011 | Dennis C. Koester; Shahid I. Awan; Daniel B. Werz, ChemBioChem, 2011

Self‐denunciation: The trehalose mycolyltransferases have such a broad substrate scope that even fluorescently labelled derivatives are well processed. This can be used to image bacteria such as M. tuberculosis in vitro and in vivo without disturbing either the bacteria's growth or their ...

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A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii

05-Sep-2011 | Sibongile Mafu; Matthew L. Hillwig; Reuben J. Peters, ChemBioChem, 2011

Two‐in‐one enzyme: A bifunctional diterpene synthase from the lycophyte Selaginella moellendorffii has been characterized. The structure of its product, labda‐7,13E‐dien‐15‐ol, demonstrates that this enzyme catalyzes a novel class II diterpene cyclization reaction, and clarifies the biosynthetic ...

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Antibody‐Free Detection of Protein Tyrosine Nitration in Tissue Sections

05-Sep-2011 | Rosalina Wisastra; Klaas Poelstra; Rainer Bischoff; Harm Maarsingh; Hidde J. Haisma; Frank J. Dekker, ChemBioChem, 2011

Inflamed proteins: Tyrosine nitration is a covalent post‐translational protein modification that represents a biomarker for inflammatory diseases. We introduce a novel method to detect nitrotyrosine in biological samples by chemoselective conversion into a fluorophore. We describe the ...

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Biosynthesis of Sesquiterpenes by the Fungus Fusarium verticillioides

05-Sep-2011 | Jeroen S. Dickschat; Nelson L. Brock; Christian A. Citron; Bettina Tudzynski, ChemBioChem, 2011

Abstract The volatiles of the fungus Fusarium verticillioides were analysed by GC‐MS. Sesquiterpenes dominated, with trichodiene as the principle component. Several other sesquiterpenes were detected in low amounts that were unambiguously identified from their mass spectra and retention ...

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Increased Promiscuity of Human Galactokinase Following Alteration of a Single Amino Acid Residue Distant from the Active Site

05-Sep-2011 | Helena Kristiansson; David J. Timson, ChemBioChem, 2011

Abstract Galactokinase catalyses the site‐ and stereospecific phosphorylation of galactose at the expense of ATP. The specificity of bacterial galactokinase enzymes can be broadened by alteration of a tyrosine residue to a histidine. The effects of altering the equivalent residue in human ...

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Structural Basis of Bcl‐xL Recognition by a BH3‐Mimetic α/β‐Peptide Generated by Sequence‐Based Design

05-Sep-2011 | Erinna F. Lee; Brian J. Smith; W. Seth Horne; Kelsey N. Mayer; Marco Evangelista; Peter M. Colman; Samuel H. Gellman ..., ChemBioChem, 2011

Abstract The crystal structure of a complex between the prosurvival protein Bcl‐xL and an α/β‐peptide 21‐mer is described. The α/β‐peptide contains six β‐amino acid residues distributed periodically throughout the sequence and adopts an α‐helix‐like conformation that mimics the bioactive shape ...

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