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1,421 Newest Publications in chemical research in toxicology

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α,β-Unsaturated Aldehyde-Induced Delays in Nucleotide Excision Repair and the Contribution of Reactive Oxygen Species

17-Jan-2018 | Guang Yang; Yuko Ibuki, Chemical Research in Toxicology, 2018

Aldehydes are widespread environmental and industrial compounds to which humans are frequently exposed. Despite their significant health risk, the mechanisms underlying aldehyde toxicity are poorly understand. We recently demonstrated that cigarette sidestream smoke (CSS) inhibited nucleotide ...

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Structural Identification and Kinetic Analysis of the in Vitro Products Formed by Reaction of Bisphenol A-3,4-quinone with N-Acetylcysteine and Glutathione

16-Jan-2018 | Douglas E. Stack; John A. Conrad; Bejan Mahmud, Chemical Research in Toxicology, 2018

Bisphenol A (BPA) has received considerable attention as an endocrine disrupting chemical and a possible substrate for genotoxic metabolites. BPA metabolism leads to formation of electrophilic o-quinones cable of binding to DNA and other endogenous nucleophiles. We have structurally identified ...

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Nucleic Bases Alkylation with Acrylonitrile and Cyanoethylene Oxide: A Computational Study

12-Jan-2018 | Martin Gladovic; Eva Spaninger; Urban Bren, Chemical Research in Toxicology, 2018

Acrylonitrile (AN) is widely used in the manufacture of resins, plastics, and polymers, where workers are exposed to it during its production, transportation, and application. After intake a portion of AN is converted to cyanoethylene oxide (CEO) by cytochrome P450 2E1. Both AN and CEO represent ...

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Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

11-Jan-2018 | Shalenie P. den Braver-Sewradj; Michiel W. den Braver; Robin M. Toorneman; Stephanie van Leeuwen; Yongjie Zhang; Ste ..., Chemical Research in Toxicology, 2018

Detoxicating enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like compounds. The protective role of the polymorphic NQO1 and NQO2 enzymes is especially of interest in the liver as the major site of drug ...

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A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

06-Oct-2017 | Rui Sun; Fuguo Shi; Keke Liu; Ling Fu; Caiping Tian; Yong Yang; Keri A. Tallman; Ned A. Porter; Jing Yang, Chemical Research in Toxicology, 2017

Reactive metabolites (RM) formed from bioactivation of drugs can covalently modify liver proteins and cause mechanism-based inactivation of major cytochrome P450 (CYP450) enzymes. Risk of bioactivation of a test compound is routinely examined as part of lead optimization efforts in drug ...

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Synthesis, Characterization, and Identification of New in Vitro Covalent DNA Adducts of Divinyl Sulfone, an Oxidative Metabolite of Sulfur Mustard

05-Oct-2017 | Shanshan Lv; Yajiao Zhang; Bin Xu; Hua Xu; Yumei Zhao; Jia Chen; Zhongcai Gao; Jianfeng Wu; Jianwei Xie, Chemical Research in Toxicology, 2017

Divinyl sulfone (DVS) is an important oxidative metabolic product of sulfur mustard (SM) in vitro and in vivo. Although DVS is not a classical blister agent, its high reactivity and toxicity induced by vinyl groups can also cause blisters like SM upon contact with the skin, eyes, and respiratory ...

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Detoxification of Atrazine by Low Molecular Weight Thiols in Alfalfa (Medicago sativa)

04-Oct-2017 | Jing Jing Zhang; Jiang Yan Xu; Feng Fan Lu; She Feng Jin; Hong Yang, Chemical Research in Toxicology, 2017

Low molecular weight (LMW) thiols in higher plants are a group of sulfur-rich nonprotein compounds and play primary and multiple roles in cellular redox homeostasis, enzyme activities, and xenobiotics detoxification. This study focused on identifying thiols-related protein genes from the legume ...

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Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms

03-Oct-2017 | Maha S. Al-Keilani; Nour A. Al-Sawalha, Chemical Research in Toxicology, 2017

Despite the advancement in cancer therapy, a high number of patients fail treatment because of drug resistance. Several preclinical in vitro data suggest that phenylbutyrate has antiproliferative, antiangiogenic, antimetastatic, immunomodulatory, and differentiating properties. Moreover, ...

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“Juice Monsters”: Sub-Ohm Vaping and Toxic Volatile Aldehyde Emissions

29-Sep-2017 | Soha Talih; Rola Salman; Nareg Karaoghlanian; Ahmad El-Hellani; Najat Saliba; Thomas Eissenberg; Alan Shihadeh, Chemical Research in Toxicology, 2017

An emerging category of electronic cigarettes (ECIGs) is sub-Ohm devices (SODs) that operate at ten or more times the power of conventional ECIGs. Because carcinogenic volatile aldehyde (VA) emissions increase sharply with power, SODs may expose users to greater VAs. In this study, we compared VA ...

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Dose-Dependent Response to 3-Nitrobenzanthrone Exposure in Human Urothelial Cancer Cells

28-Sep-2017 | Mario Pink; Nisha Verma; Anna Zerries; Simone Schmitz-Spanke, Chemical Research in Toxicology, 2017

A product of incomplete combustion of diesel fuel, 3-nitrobenzanthrone (3-NBA), has been classified as a cancer-causing substance. It first gained attention as a potential urinary bladder carcinogen due to the presence of its metabolite in urine and formation of DNA adducts. The aim of the ...

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