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Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva

21-Jan-2016 | Wanklyn, Ceri; Burton, Dan; Enston, Emma; Bartlett, Carrie-Ann; Taylor, Sarah; Raniczkowska, Aleksandra; Black, Murd ..., Chemistry Central Journal , 2016

Background: Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the psychoactive component of cannabis, is highly desirable for ...


Spectral, thermal, molecular modeling and biological studies on mono- and binuclear complexes derived from oxalo bis(2,3-butanedionehydrazone)

29-Dec-2015 | El-Asmy, Ahmed; Jeragh, Bakir; Ali, Mayada, Chemistry Central Journal , 2015

Background: Hydrazones and their metal complexes were heavily studied due to their pharmacological applications such as antimicrobial, anticonvulsant analgesic, anti-inflammatory and anti-cancer agents. This work aims to synthesize and characterize novel complexes of VO ...


Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health

24-Dec-2015 | Lv, Xinmiao; Zhao, Siyu; Ning, Zhangchi; Zeng, Honglian; Shu, Yisong; Tao, Ou; Xiao, Cheng; Lu, Cheng; Liu, Yuanyan, Chemistry Central Journal , 2015

Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian ...


Thermodynamic properties of 5(nitrophenyl) furan-2-carbaldehyde isomers

09-Dec-2015 | Dibrivnyi, Volodymyr; Sobechko, Iryna; Puniak, Marian; Horak, Yuriy; Obushak, Mykola; Van-Chin-Syan, Yuriy; Andriy, ..., Chemistry Central Journal , 2015

Background: The aim of the current work was to determine thermo dynamical properties of 5(2-nitro phenyl)-furan-2-carbaldehyde, 5(3-nitro phenyl)-furan-2-carbaldehyde and 5(4-nitro phenyl)-furan-2-carbaldehyde. Results: The temperature dependence of saturated vapor pressure of 5(2-nitro ...


Tissue-specific metabolite profiling and quantitative analysis of ginsenosides in Panax quinquefolium using laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry

09-Dec-2015 | Chen, Yujie; Xu, Liang; Zhao, Yuancen; Zhao, Zhongzhen; Chen, Hubiao; Yi, Tao; Qin, Minjian; Liang, Zhitao, Chemistry Central Journal , 2015

Background: The root of Panax quinquefolium L., famous as American ginseng all over the world, is one of the most widely-used medicinal or edible materials. Ginsenosides are recognized as the main bioactive chemical components responsible for various functions of American ginseng. In this study, ...


Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

26-Nov-2015 | Chen, Xi; Barclay, Jeff W; Burgoyne, Robert D; Morgan, Alan, Chemistry Central Journal , 2015

Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these conditions provide only symptomatic relief. ...


Silica-titania xerogel for solid phase spectrophotometric determination of salicylate and its derivatives in biological liquids and pharmaceuticals

25-Nov-2015 | Morosanova, Maria A; Morosanova, Elena I, Chemistry Central Journal , 2015

Background: Salicylic acid and its derivatives are widely used drugs with potential toxicity. The main areas of salicylate derivatives determination are biological liquids and pharmaceuticals analysis. Results: Silica-titania xerogel has been used for solid phase spectrophotometric determination ...


Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors

17-Nov-2015 | Barakat, Assem; Al-Majid, Abdullah M; Lotfy, Gehad; Arshad, Fiza; Yousuf, Sammer; Choudhary, M. I; Ashraf, Sajda; Ul ..., Chemistry Central Journal , 2015

Background: Discovery of potent inhibitors of urease (jack bean) enzyme is the first step in the development of drugs against diseases caused by ureolytic enzyme. Results: Thirty-two derivatives of barbituric acid as zwitterionic adducts of diethyl ammonium salts were synthesized. All synthesized ...


Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data

05-Nov-2015 | Pizzo, Fabiola; Gadaleta, Domenico; Lombardo, Anna; Nicolotti, Orazio; Benfenati, Emilio, Chemistry Central Journal , 2015

Background: The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, ...


Biosynthesis of silver nanoparticles using Artocarpus elasticus stem bark extract

02-Nov-2015 | Abdullah, Nur ISB; Ahmad, Mansor B; Shameli, Kamyar, Chemistry Central Journal , 2015

Background: Green approach in synthesizing metal nanoparticles has gain new interest from the researchers as metal nanoparticles were widely applied in medical equipment and household products. The use of plants in the synthesis of nanoparticles emerges as a cost effective and eco-friendly ...


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