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17,838 Newest Publications in journal of the american chemical society
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Traceless Silylation of β-C(sp3)–H Bonds of Alcohols via Perfluorinated Acetals
19-Jan-2018 | Ala Bunescu; Trevor W. Butcher; John F. Hartwig, Journal of the American Chemical Society, 2018
We report the silylation of primary C–H bonds located β to secondary and tertiary alcohols by exploiting perfluorinated esters as traceless directing groups. The conversion of a secondary or tertiary alcohol to a perfluoroalkyl ester and conversion of the ester to the corresponding silyl acetals ...
Unconventional Fragment Usage Enables a Concise Total Synthesis of (−)-Callyspongiolide
19-Jan-2018 | Francesco Manoni; Corentin Rumo; Liubo Li; Patrick G. Harran, Journal of the American Chemical Society, 2018
Journal of the American Chemical Society DOI: 10.1021/jacs.7b13591
1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility
19-Jan-2018 | Wan-Qiu Liu; Patricia Amara; Jean-Marie Mouesca; Xinjian Ji; Oriane Renoux; Lydie Martin; Chen Zhang; Qi Zhang; Yvai ..., Journal of the American Chemical Society, 2018
Regiospecific dehydration of vicinal diols by enzymes is a difficult reaction that usually requires activation by dedicated organic cofactors. The enzymatic use of radical-based chemistry is an effective but challenging alternative as radical intermediates are difficult to control. Here we report ...
Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups
19-Jan-2018 | Arismel Tena Meza; Thomas Wurm; Lewis Smith; Seung Wook Kim; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische, Journal of the American Chemical Society, 2018
Journal of the American Chemical Society DOI: 10.1021/jacs.7b13482
Hidden Beneath the Surface: Origin of the Observed Enantioselective Adsorption on PdGa(111)
19-Jan-2018 | Aliaksandr V. Yakutovich; Johannes Hoja; Daniele Passerone; Alexandre Tkatchenko; Carlo A. Pignedoli, Journal of the American Chemical Society, 2018
We unravel the origin of the recently observed striking enantioselectivity of the PdGa(111) surface with respect to the adsorption of a small organic molecule, 9-ethynylphenanthrene, using first-principles calculations. It turns out that the key ingredient to understand the experimental evidence ...
Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria
19-Jan-2018 | Hongjian He; Jiaqing Wang; Huaimin Wang; Ning Zhou; Dongsik Yang; Douglas R. Green; Bing Xu, Journal of the American Chemical Society, 2018
Most of the reported mitochondria-targeting molecules are lipophilic and cationic, and thus they may become cytotoxic with accumulation. Here we show enzymatic cleavage of branched peptides that carry negative charges for targeting mitochondria. Conjugating a well-established protein tag (i.e., ...
Ultrafast Observation of a Photoredox Reaction Mechanism: Photoinitiation in Organocatalyzed Atom-Transfer Radical Polymerization
19-Jan-2018 | Daisuke Koyama; Harvey J. A. Dale; Andrew J. Orr-Ewing, Journal of the American Chemical Society, 2018
Photoredox catalysis has driven a revolution in the field of organic chemistry, but direct mechanistic insights into reactions of genuine synthetic utility remain relatively scarce. Herein we report ultrafast time-resolved spectroscopic observation of a bimolecular organocatalyzed photoredox ...
Defect-Free Encapsulation of Fe0 in 2D Fused Organic Networks as a Durable Oxygen Reduction Electrocatalyst
19-Jan-2018 | Seok-Jin Kim; Javeed Mahmood; Changmin Kim; Gao-Feng Han; Seong-Wook Kim; Sun-Min Jung; Guomin Zhu; James J. De Yore ..., Journal of the American Chemical Society, 2018
Because they provide lower cost but comparable activity to precious platinum (Pt)-based catalysts, nonprecious iron (Fe)-based materials, such as Fe/Fe3C and Fe–N–C, have gained considerable attention as electrocatalysts for the oxygen reduction reaction (ORR). However, their practical ...
Red-Light-Driven Water Splitting by Au(Core)–CdS(Shell) Half-Cut Nanoegg with Heteroepitaxial Junction
19-Jan-2018 | Shin-ichi Naya; Takahiro Kume; Ryo Akashi; Musashi Fujishima; Hiroaki Tada, Journal of the American Chemical Society, 2018
A key material for artificial photosynthesis including water splitting is heteronanostructured (HNS) photocatalysts. The photocatalytic activity depends on the geometry and dimension, and the quality of junctions between the components. Here we present a half-cut Au(core)–CdS(shell) (HC-Au@CdS) ...
Chemical Design of Both a Glutathione-Sensitive Dimeric Drug Guest and a Glucose-Derived Nanocarrier Host to Achieve Enhanced Osteosarcoma Lung Metastatic Anticancer Selectivity
19-Jan-2018 | Lu Su; Richen Li; Sarosh Khan; Ryan Clanton; Fuwu Zhang; Yen-Nan Lin; Yue Song; Hai Wang; Jingwei Fan; Soleil Hernan ..., Journal of the American Chemical Society, 2018
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers and one dimeric prodrug molecule were designed to ...
