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4,008 Newest Publications in lab on a chip


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Hydrogel electrodeposition based on bipolar electrochemistry

03-Jul-2018 | Kosuke Ino; Tomoaki Matsumoto; Noriko Taira; Tatsuki Kumagai; Yuji Nashimoto; Hitoshi Shiku, Lab on a Chip, 2018

Bipolar electrochemistry has attracted great interest for applications based on sensing, electrografting, and electrodeposition, because the technique enables electrochemical reactions to be induced at multiple bipolar electrodes (BPEs) with only a single power supply. However, there are only a ...


Formation of arrays of planar, murine, intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone

03-Jul-2018 | Raehyun Kim; Yuli Wang; Shee-Hwan J. Hwang; Peter J. Attayek; Nicole M. Smiddy; Mark I. Reed; Christopher E. Sims; N ..., Lab on a Chip, 2018

A simple, in vitro intestinal model recapitulating key aspects of crypt architecture and physiology would facilitate our understanding the impact of drugs, foods and microbial metabolites on the intestine. To address the limitations of previously reported intestinal in vitro platforms, we ...


A fluorometric skin-interfaced microfluidic device and smartphone imaging module for in situ quantitative analysis of sweat chemistry

03-Jul-2018 | Yurina Sekine; Sung Bong Kim; Yi Zhang; Amay J. Bandodkar; Shuai Xu; Jungil Choi; Masahiro Irie; Tyler R. Ray; Punit ..., Lab on a Chip, 2018

The rich composition of solutes and metabolites in sweat and its relative ease of collection upon excretion from skin pores make this class of biofluid an attractive candidate for point of care analysis. Wearable technologies that combine electrochemical sensors with conventional or emerging ...


Enhancement of radionuclide bio-decontamination by screening highly efficient microalgae for Sr biomineralization

03-Jul-2018 | Cong Wang; Keon Ah Lee; Eunpyo Choi; Keun-Young Lee; Seung-Yop Lee; Kwang Hwan Jung; Jungyul Park, Lab on a Chip, 2018

In this study, a new strategy for improving the radionuclide bio-decontamination (RBD) activity of microalgae by screening a better strain with high potential of biomineral production has been proposed. A noninvasive dielectrophoresis (DEP)-based microalgae screening microplatform has been used ...


An acoustofluidic trap and transfer approach for organizing a high density single cell array

27-Jun-2018 | Korine A. Ohiri; Sean T. Kelly; Jeffrey D. Motschman; Kevin H. Lin; Kris C. Wood; Benjamin B. Yellen, Lab on a Chip, 2018

We demonstrate a hybrid microfluidic system that combines fluidic trapping and acoustic switching to organize an array of single cells at high density. The fluidic trapping step is achieved by balancing the hydrodynamic resistances of three parallel channel segments forming a microfluidic ...


3D cell electrorotation and imaging for measuring multiple cellular biophysical properties

26-Jun-2018 | Liang Huang; Peng Zhao; Wenhui Wang, Lab on a Chip, 2018

3D rotation is one of many fundamental manipulations to cells and imperative in a wide range of applications in single cell analysis involving biology, chemistry, physics and medicine. In this article, we report a dielectrophoresis-based, on-chip manipulation method that can load and rotate ...


Crystal-on-crystal chips for in situ serial diffraction at room temperature

26-Jun-2018 | Zhong Ren; Medine Ayhan; Sepalika Bandara; Kalinga Bowatte; Indika Kumarapperuma; Semini Gunawardana; Heewhan Shin; ..., Lab on a Chip, 2018

Recent developments in serial crystallography at X-ray free electron lasers (XFELs) and synchrotrons have been driven by two scientific goals in structural biology – first, static structure determination from nano or microcrystals of membrane proteins and large complexes that are difficult for ...


Surface acoustic wave diffraction driven mechanisms in microfluidic systems

26-Jun-2018 | Armaghan Fakhfouri; Citsabehsan Devendran; Thomas Albrecht; David John Collins; Andreas Winkler; Hagen Schmidt; Adri ..., Lab on a Chip, 2018

Acoustic forces arising from high-frequency surface acoustic waves (SAW) underpin an exciting range of promising techniques for non-contact manipulation of fluid and objects at micron scale. Despite increasing significance of SAW-driven technologies in microfluidics, the understanding of a broad ...


Low-power, low-cost urinalysis system with integrated dipstick evaluation and microscopic analysis

26-Jun-2018 | Gennifer T. Smith; Linkai Li; Yue Zhu; Audrey K. Bowden, Lab on a Chip, 2018

We introduce a coupled dipstick and microscopy device for analyzing urine samples. The device is capable of accurately assessing urine dipstick results while simultaneously imaging the microscopic contents within the sample. We introduce a long working distance, cellphone-based microscope in ...


Micro/nano acoustofluidics: materials, phenomena, design, devices, and applications

26-Jun-2018 | William Connacher; Naiqing Zhang; An Huang; Jiyang Mei; Shuai Zhang; Tilvawala Gopesh; James Friend, Lab on a Chip, 2018

Acoustic actuation of fluids at small scales may finally enable a comprehensive lab-on-a-chip revolution in microfluidics, overcoming long-standing difficulties in fluid and particle manipulation on-chip. In this comprehensive review, we examine the fundamentals of piezoelectricity, piezoelectric ...


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