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9,059 Newest Publications in organic & biomolecular chemistry
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03-Jul-2018 | Yin-He Yang; Bin Di; Da-Song Yang, Organic & Biomolecular Chemistry, 2018
A counterintuitive freezing-induced peptide ligation was discovered in the total synthesis of human interferon-ε (hIFN-ε) which blocks HIV infection through unique mechanisms. The successful synthesis of hIFN-ε (187 amino acids) in this research laid the foundation for related anti-AIDS drug ...
03-Jul-2018 | Fei Yang; Yangshan Li; Paul E. Floreancig; Xiaoyan Li; Lei Liu, Organic & Biomolecular Chemistry, 2018
An efficient copper-catalyzed cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes mediated by DDQ has been established. A protic additive, EtOH, proved to be crucial for harmonizing the oxidation with a subsequent alkynylation step by retaining the oxidation state of an ...
03-Jul-2018 | Kamaljeet Singh; Winston Trinh; Jimmie D. Weaver, Organic & Biomolecular Chemistry, 2018
A mild and operationally simple methodology is reported for the synthesis of cyclobutane rings imbedded within a C2-symmetric tricyclic framework. The method uses visible light and an iridium-based photocatalyst to drive the oft-stated “forbidden” thermal [2 + 2] cycloaddition of cycloheptenes ...
03-Jul-2018 | Long Chen; Yueyue Zhu; Tieqiao Chen; Long Liu; Ji-Shu Zhang; Li-Biao Han, Organic & Biomolecular Chemistry, 2018
A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed the readily available alcohols and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3C-P bonds. A reasonable ...
03-Jul-2018 | Poojan Milan Gharat; Dilip Kumar Maity; Haridas Pal; Sharmistha Dutta Choudhury, Organic & Biomolecular Chemistry, 2018
This study explores the interesting effect of p-sulfonatocalix[n]arene hosts (SCXn) on the excited-state tautomeric equilibrium of Chrysazine (CZ), a model antitumour drug molecule. Detailed photophysical investigations reveal that conversion of CZ from its excited normal form (N*) to the ...
03-Jul-2018 | Anna Lielpetere; Aigars Jirgensons, Organic & Biomolecular Chemistry, 2018
Fragmentation of electrochemically generated oxonium ions can be exploited to form carbenium ions at low oxidation potential in the presence of a nuclephile. The application of this concept is demonstrated for allylation of carbenium ions generated by anodic oxidation of ...
03-Jul-2018 | Fang Yuan; Yuan Tian; Weirong Qin; Jingxu Li; Dan Yang; Bing-Chuan Zhao; Feng Yin; Zigang Li, Organic & Biomolecular Chemistry, 2018
Antimicrobial peptides (AMPs) are short cationic peptides with a high affinity for membranes and emerged as a promising therapeutic approach with potential for treating infectious diseases. Chemical stabilization of short peptides proved to be a successful approach for enhancing their ...
03-Jul-2018 | Helena Martin-Gómez; Judit Tulla-Puche, Organic & Biomolecular Chemistry, 2018
The discovery and development of novel constrained peptides that combine the advantages of therapeutic proteins with those of small molecules has partially prompted the re-emergence of peptides as therapeutics. In this regard, lasso peptides are characterized by both the selectivity and potency ...
03-Jul-2018 | María Fernanda García; Fabio Gallazzi; Mara de Souza Junqueira; Marcelo Fernández; Ximena Camacho; J ..., Organic & Biomolecular Chemistry, 2018
Pretargeted imaging, based on the highly reactive process between [1,2,4,5]tetrazines with trans-cyclooctene (TCO), appears as an attractive strategy to overcome disadvantages associated with traditional radioimmunoconjugates. To be successful, the radiolabeled component should react in vivo with ...
03-Jul-2018 | Jeyakumar Kandasamy; Adesh Kumar Singh, Organic & Biomolecular Chemistry, 2018
A stereocontrolled synthesis of aryl-C-glycosides was achieved using glycals and aryldiazonium salts in the presence of palladium acetate. A wide range of glycals including D-glucal, D-galactal, L-rhamanal, D-xylal and D-ribal underwent C-arylation at the anomeric carbon in the presence of ...