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1,822 Newest Publications in rapid communications in mass spectrometry


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In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC‐MS/MS

15-Jan-2018 | Wenchao Sun, Khoa Dinh Nguyen, William L. Fitch, Samuel D. Banister, Hongxiang Tang, Xiaolan Zhang, Lewis Yu, Edgar ..., Rapid Communications in Mass Spectrometry, 2018

Abstract Rationale A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator–activated receptor γ coactivator 1α (PGC‐1α) in certain metabolic tissues. Upregulation of PGC‐1α by ZLN005 has been shown to have beneficial effect in ...


Naturally occurring Chrysophanol as MALDI matrix for the analysis of a broad spectrum of analytes

15-Jan-2018 | Sukanya Pandeti, Naga Veera Yerra, N. Prasada Raju, Jagadeshwar Reddy Thota, Rapid Communications in Mass Spectrometry, 2018

Rationale Chrysophanol (CP), 1, 8-Dihydroxy-3-methylanthraquinone, is a naturally occurring anthraquinone and is the major bioactive compound of numerous herb species.The CP has been successfully used for its therapeutic properties in many medical scenarios. In the search for new and more ...


Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography‐Tandem Mass Spectrometry (LC‐MS/MS)

09-Jan-2018 | Nhi Phung, Karen Kuncze, Hideaki Okochi, Alexander Louie, Leslie Z. Benet, Igho Ofokotun, David W. Haas, Judith S. C ..., Rapid Communications in Mass Spectrometry, 2018

Abstract Assays to quantify antiretrovirals in hair samples are increasingly used to monitor adherence and exposure in both HIV prevention and treatment studies. Atazanavir (ATV) is a protease inhibitor used in combination antiretroviral therapy (ART). We developed and validated a liquid ...


Liquid Chromatography‐Mass Spectrometry for the Detection of Ash Tree Metabolites following Emerald Ash Borer Infestation

06-Jan-2018 | Naomi L. Stock, Michael.C. Doran, Ron F. Bonner, Raymond.E. March, Rapid Communications in Mass Spectrometry, 2018

Abstract Rationale The Emerald Ash Borer (EAB), Agrilus planipennis, an invasive insect detected in the U.S.A. and Canada in 2002, is a threat to ash trees with both ecological and economic implications. Early detection of EAB‐infestation is difficult due to lack of visible signs and ...


Microdialysis sampling combined with ultra‐high‐performance liquid chromatography‐tandem mass spectrometry for the determination of geniposide in dialysate of joint cavities in adjuvant arthritis rats

05-Jan-2018 | Wen‐Yu Wang, Wei Wang, Hong Wu, Shu‐Ping Li, Rong Wang, Li Dai, Zheng‐Rong Zhang, Jun Fu, Ran Deng, Feng Li, Rapid Communications in Mass Spectrometry, 2018

Abstract Rationale Microdialysis has been used to detect the concentrations of drugs in tissues. Geniposide (GE), an iridoid glycoside compound, is the main bioactive component of Gardenia jasminoides Ellis fruit. We previously demonstrated that GE could control the activity of cytokines and ...


Using “isotopic spike” from tropical storm to understand water exchange on large scale: case study of Hurricane Rafael in the Lesser Antilles archipelago, October 2012.

03-Jan-2018 | Luc Lambs, Félix Bompy, Maguy Dulormne, Rapid Communications in Mass Spectrometry, 2018

Abstract Rationale Studies of wetland eco‐hydrology in tropical coastal area are scarce, and the use of water stable isotopes can be of great help. Key constraints for their analysis are (i) the small difference in δ18O values between seawater and old evaporated freshwater, and (ii) the fact ...


Coalescence and self‐bunching observed in commercial high‐resolution mass spectrometry instrumentation

03-Jan-2018 | Anton Kaufmann, Stephan Walker, Rapid Communications in Mass Spectrometry, 2018

Abstract Rationale Self‐bunching and coalescence are well‐known effects in Fourier transform ion cyclotron resonance (FTICR) and multi‐reflection time‐of‐flight (TOF) mass spectrometry. These detrimental effects can also be observed in currently more frequently used high‐resolution mass ...


Metabolism of bisphenol S in mice after oral administration

27-Dec-2017 | Yuanyuan Song, Peisi Xie, Zongwei Cai, Rapid Communications in Mass Spectrometry, 2017

Abstract Rational As an important substitute of bisphenol A (BPA), bisphenol S (BPS) shows comparable estrogenic effects. BPS is now widely used in consumer products with widespread human exposures. In order to evaluate the health risk of BPS, it is essential to develop a rapid method for ...


A simple and reliable method reducing sulfate to sulfide for multiple sulfur isotope analysis

22-Dec-2017 | Lei Geng, Joel Savarino, Clara Savarino, Nicolas Caillon, Pierre Cartigny, Shohei Hattori, Sakiko Ishino, Naohiro Yo ..., Rapid Communications in Mass Spectrometry, 2017

Abstract Rationale Precise analysis of four sulfur isotopes of sulfate in geological and environmental samples provides the means to extract unique information in wide geological contexts. Reduction of sulfate to sulfide is the first step to access such information. The conventional ...


Effects of sample cleaning and storage on the elemental composition of shark vertebrae

16-Nov-2017 | John A. Mohan, Thomas C. TinHan, Nathan R. Miller, R.J. David Wells, Rapid Communications in Mass Spectrometry, 2017

Abstract Rationale Application of vertebral chemistry in elasmobranchs has the potential to progress our understanding of individual migration patterns and population dynamics. However, the influence of handling artifacts such as sample cleaning and storage on vertebral chemistry is unclear ...


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