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3,062 Newest Publications of Bentham Science Publishers


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A Novel Azo-Calixaren Derivative Based on 2,6-diamino Pyridine: Synthesis, Characterization and Antibacterial Evaluation

28-Jun-2017 | Rahnama Lakomehsari, Kaabeh; Taghvaei Ganjali, Saeed; Zadmard, Reza; Roshan, Mina, Letters in Organic Chemistry, 2017

Abstract: Background: Azocalix[4] arene derivative based on 2,6-diamino pyridine has been synthesized from diazo-coupling reaction between tetradiazonium salt of calix[4]arene and 2,6-diaminopyridine, and characterized by various spectroscopic methods such as IR, 1HNMR, 13CNMR and Mass ...


MSD-MAP: A Network-Based Systems Biology Platform for Predicting Disease-Metabolite Links

28-Jun-2017 | Wathieu, Henri; T. Issa, Naiem; Mohandoss, Manisha; W. Byers, Stephen; Dakshanamurthy, Sivanesan, Combinatorial Chemistry, 2017

Abstract: Background: Cancer-associated metabolites result from cell-wide mechanisms of dysregulation. The field of metabolomics has sought to identify these aberrant metabolites as disease biomarkers, clues to understanding disease mechanisms, or even as therapeutic agents. Objective: This ...


Antimalarials: Molecular Drug Targets and Mechanism of Action

28-Jun-2017 | O. Achieng, Angela; Rawat, Manmeet; Ogutu, Bernhards; Guyah, Bernard; Michael Ong'echa, John; J. Perkins, Douglas; K ..., Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Despite a reduction in the global burden of malaria, the disease remains responsible for 214 million cases and 438,000 deaths annually with 88% of the mortality occurring in sub-Saharan Africa. Malaria control largely depends on effective chemotherapy. However, the ...


InsP3 Signaling in Apicomplexan Parasites

28-Jun-2017 | R.S. Garcia, Celia; Alves, Eduardo; H. S. Pereira, Pedro; J. Bartlett, Paula; P. Thomas, Andrew; Mikoshiba, Katsuhik ..., Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell functions. Specifically, the ability to generate myo-inositol 1,4,5-trisphosphate (InsP3) via phospholipase C ...


Exploration of New and Potent Lead Molecules Against CAAX Prenyl Protease I of Leishmania donovani Through Pharmacophore Based Virtual Screening Approach

28-Jun-2017 | Vijaya Prabhu, Sitrarasu; Tiwari, Kartikeya; Suryanarayanan, Venkatesan; Kumar Dubey, Vikash; Kumar Singh, Sanjeev, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: Visceral leishmaniasis is a deadly disease left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anemia. It is highly endemic in the Indian subcontinent. CAAX prenyl protease I ...


In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site

28-Jun-2017 | M. Kamble, Sarika; M. Patel, Harun; N. Goyal, Sameer; N. Noolvi, Malleshappa; B. Mahajan, Umesh; Ojha, Shreesh; R. P ..., Combinatorial Chemistry, 2017

Abstract: Aim and Objective: Kelch like ECH-associated protein 1 (Keap1) and Nuclear factor-E2 related factor 2 (Nrf2) binding is a key step in the ubiquitination and degradation of Nrf2. The compounds inhibiting this binding exert antioxidant actions. Naturally occurring pentacyclic ...


Combined Approach of QSAR and Docking Studies for the Design of Local Anaesthetic Agents

28-Jun-2017 | Zhang, Chunyan; Li, Zhi; Ma, Jiahai; Zhang, Jing; Zhang, Longming; Li, Tao; Zheng, Shijian, Combinatorial Chemistry, 2017

Abstract: Background: Heterocyclic scaffold, benzotriazole and its derivatives are potential anaesthetic agents that act locally. Objective: QSAR and docking analysis of previously synthesized benzotriazolyl derivatives were modelled for their local anaesthetic action using computer ...


Protein Modeling and Molecular Dynamics Simulation of Cloned Regucalcin (RGN) Gene from Bubalus bubalis

28-Jun-2017 | Pillai, Harikrishna; Singh Yadav, Brijesh; Chaturvedi, Navaneet; Tasleem Jan, Arif; Kumar Gupta, Girish; Hassan Baig ..., Combinatorial Chemistry, 2017

Abstract: Background: Regucalcin (RGN), a calcium regulating protein having anti-prolific, antiapoptotic functions, plays important part in the biosynthesis of ascorbic acid. It is a highly conserved protein that has been reported from many tissue types of various vertebrate species. ...


Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication

28-Jun-2017 | Kadian, Kavita; Gupta, Yash; Kempaiah, Prakasha; Gupta, Nikesh; Sharma, Arun; Rawat, Manmeet, Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic ...


An Overview of Currently Available Antimalarials

28-Jun-2017 | Yu. Gorobets, Nikolay; V. Sedash, Yuriy; K. Singh, Brajendra; Poonam; Rathi, Brijesh, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health. Objective: Overview of ...


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