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131 Newest Publications of Libertas Academica

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Organ-on-a-Chip: New Platform for Biological Analysis

01-Dec-2015 | Fan An, Yueyang Qu, Xianming Liu, Runtao Zhong and Yong Luo, Analytical Chemistry Insights, 2015

Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on ...

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Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review

17-Nov-2015 | Mrudul R. Keskar and Ravin M. Jugade, Analytical Chemistry Insights, 2015

Macrolides, one of the most commonly used class of antibiotics, are a group of drugs produced by Streptomyces species. They belong to the polyketide class of natural products. Their activity is due to the presence of a large macrolide lactone ring with deoxy sugar moieties. They are protein ...

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Immunohistochemical Markers of Soft Tissue Tumors: Pathologic Diagnosis, Genetic Contributions, and Therapeutic Options

03-Nov-2015 | David M. Parham, Analytical Chemistry Insights, 2015

After ~30 years of widespread usage, immunohistochemistry (IHC) has become a standard method of diagnosis for surgical pathology. Because of the plethora of diagnoses and often subtle nature of diagnostic criteria, IHC finds particular utility in soft tissue tumors. The use of progressively small ...

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Organophosphate Hydrolase in Conductometric Biosensor for the Detection of Organophosphate Pesticides

14-Oct-2015 | Ani Mulyasuryani and Sasangka Prasetyawan, Analytical Chemistry Insights, 2015

The research has developed an enzyme biosensor for the detection organophosphate pesticide residues. The biosensor consists of a pair of screen-printed carbon electrode (SPCEs). One of electrodes contains immobilized organophosphate hydrolase (OPH) on a chitosan membrane by cross-linking it with ...

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Determination and Validation of a Solid-phase Extraction Gas Chromatography-mass Spectrometry for the Quantification of Methadone and Its Principal Metabolite in Human Plasma

02-Sep-2015 | Fouad Chiadmi and Joël Schlatter, Analytical Chemistry Insights, 2015

This study aimed to develop a solid-phase extraction gas chromatography-selected ion monitoring-mass spectrometry method for the determination of methadone (MDN) and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in human plasma. The linear response was obtained over the concentration ...

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Spectrophotometric Determination of Cefixime Trihydrate in Pharmaceutical Formulations Based on Ion-Pair Reaction with Bromophenol Blue

05-Aug-2015 | Mrudul R. Keskar and Ravin M. Jugade, Analytical Chemistry Insights, 2015

Cefixime trihydrate is a broad spectrum cephalosporin antibiotic, effective against gram-positive and gram-negative bacterial infections. Simple and rapid method has been developed for the determination of cefixime trihydrate in bulk and pharmaceutical formulations. This method was based on the ...

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Determination of Chlorophenoxy Acid Methyl Esters and Other Chlorinated Herbicides by GC High-resolution QTOFMS and Soft lonization

09-Feb-2015 | Viorica Lopez-Avila, Patrick Roach and Randall Urdahl, Analytical Chemistry Insights, 2015

Gas chromatography with quadrupole time-of-flight mass spectrometry (GC-QTOFMS) and soft ionization generated by a rare-gas plasma is described here for the determination of various chlorophenoxy acid methyl esters and a few chlorinated herbicides. This plasma-based, wavelength-selectable ...

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A Study of Method Development, Validation, and Forced Degradation for Simultaneous Quantification of Paracetamol and Ibuprofen in Pharmaceutical Dosage Form by RP-HPLC Method

18-Nov-2014 | Md. Sarowar Jahan, Md. Jahirul Islam, Rehana Begum, Ruhul Kayesh and Asma Rahman, Analytical Chemistry Insights, 2014

A rapid and stability-indicating reversed phase high-performance liquid chromatography (RP-HPLC) method was developed for simultaneous quantification of paracetamol and ibuprofen in their combined dosage form especially to get some more advantages over other methods already developed for this ...

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A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides [NO + NO2] Using Rhodamine B Hydrazide as a Chemosensor

17-Aug-2014 | Pandurangappa Malingappa and Venkataramanappa Yarradoddappa, Analytical Chemistry Insights, 2014

A new chemosensor has been used to monitor atmospheric nitrogen oxides NO + NO2 at parts per billion (ppb) level. It is based on the catalytic reaction of nitrogen oxides with rhodamine B hydrazide (RBH) to produce a colored compound through the hydrolysis of the amide bond of the molecule. A ...

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