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1,991 Newest Publications of Portland Press

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Mechanisms involved in the developmental programming of adulthood disease

01-May-2010 | Warner M; Ozanne S, Biochemical Journal, 2010

There are many instances in life when the environment plays a critical role in the health outcomes of an individual, yet none more so than those experienced in fetal and neonatal life. One of the most detrimental environmental problems encountered during this critical growth period are changes in ...

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The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation

01-May-2010 | Hinton S; Myers M; Roggero V; Allison L; Tonks N, Biochemical Journal, 2010

MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein] is a pseudophosphatase member of the dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases). MK-STYX is catalytically inactive due to the absence of two amino acids from ...

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Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity

01-May-2010 | Seo P; Kim M; Song J; Kim Y; Kim H; Park C, Biochemical Journal, 2010

Changes in membrane fluidity are the earliest cellular events that occur in plant cells upon exposure to cold. This subsequently triggers physiological processes, such as calcium influx and reorganization of actin cytoskeletons, and induces expression of cold-responsive genes. The ...

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Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus

01-May-2010 | Shiryaev S; Radichev I; Ratnikov B; Aleshin A; Gawlik K; Stec B; Frisch C; Knappik A; Strongin A, Biochemical Journal, 2010

There is a need to develop inhibitors of mosquito-borne flaviviruses, including WNV (West Nile virus). In the present paper, we describe a novel and efficient recombinant-antibody technology that led us to the isolation of inhibitory high-affinity human antibodies to the active-site region of a ...

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Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters

01-May-2010 | Chen J; Randeva H, Biochemical Journal, 2010

Orexins (hypocretins), acting via their receptors, are involved in the control of feeding behaviour, sleep, arousal and energy homoeostasis. However, regulation of the human orexin receptor 2 (hOX2R) gene remains unknown. We have identified four transcripts arising from alternative splicing from ...

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MMP28 gene expression is regulated by Sp1 transcription factor acetylation

01-May-2010 | Swingler T; Kevorkian L; Culley K; Illman S; Young D; Parker A; Lohi J; Clark I, Biochemical Journal, 2010

MMP-28 (epilysin) is a recently cloned member of the MMP (matrix metalloproteinase) family. It is highly expressed in the skin by keratinocytes, the developing and regenerating nervous system and a number of other normal human tissues, as well as a number of carcinomas. The MMP28 promoter has ...

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Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis

01-May-2010 | Morohashi Y; Balklava Z; Ball M; Hughes H; Lowe M, Biochemical Journal, 2010

Secretory protein trafficking is arrested and the Golgi apparatus fragmented when mammalian cells enter mitosis. These changes are thought to facilitate cell-cycle progression and Golgi inheritance, and are brought about through the actions of mitotically active protein kinases. To better ...

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SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1

01-May-2010 | Kim K; Cho H; Kim H; Cheong J, Biochemical Journal, 2010

Gli (glioma-associated oncogene homologue) proteins act as terminal effectors of the Hedgehog signalling pathway, which is implicated in the development of many human malignancies. Gli activation is important for cell proliferation and anti-apoptosis in various cancers. Several studies have ...

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Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

01-May-2010 | Mutoh H; Hayakawa H; Sashikawa M; Sakamoto H; Sugano K, Biochemical Journal, 2010

Shh (Sonic Hedgehog) is a morphogen involved in gastric fundic gland differentiation in the adult. Shh expression is reduced in Helicobacter pylori-associated intestinal metaplastic change of the gastric epithelium and mice that lack Shh show intestinal transformation of the gastric mucosa. ...

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Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling

01-May-2010 | Liou G; Zhang H; Miller E; Seibold S; Chen W; Gallo K, Biochemical Journal, 2010

MLK3 (mixed lineage kinase 3) is a MAP3K [MAPK (mitogen-activated protein kinase) kinase kinase] that activates multiple MAPK pathways, including the JNK (c-Jun N-terminal kinase) pathway. Immunoblotting of lysates from cells ectopically expressing active MLK3 revealed an additional ...

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