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1,991 Newest Publications of Portland Press

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VDAC1 cysteine residues: topology and function in channel activity and apoptosis

01-May-2010 | Aram L; Geula S; Arbel N; Shoshan-Barmatz V, Biochemical Journal, 2010

The VDAC (voltage-dependent anion channel) is proposed to control metabolic cross-talk between mitochondria and the cytosol, as well as apoptotic cell death. It has been suggested that apoptosis is modulated by the oxidation state of VDAC. Since cysteine residues are the major target for ...

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Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3

01-May-2010 | Girvan H; Levy C; Williams P; Fisher K; Cheesman M; Rigby S; Leys D; Munro A, Biochemical Journal, 2010

Bacillus megaterium flavocytochrome P450 BM3 (CYP102A1) is a biotechnologically important cytochrome P450/P450 reductase fusion enzyme. Mutants I401E, F261E and L86E were engineered near the haem 5-methyl group, to explore the ability of the glutamate carboxylates to form ester linkages with the ...

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Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells

01-May-2010 | Faye C; Inforzato A; Bignon M; Hartmann D; Muller L; Ballut L; Olsen B; Day A; Ricard-Blum S, Biochemical Journal, 2010

Endostatin, a C-terminal fragment of collagen XVIII, binds to TG-2 (transglutaminase-2) in a cation-dependent manner. Recombinant human endostatin binds to TG-2 with an affinity in the nanomolar range (Kd=6.8nM). Enzymatic assays indicated that, in contrast with other extracellular matrix ...

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Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis

01-May-2010 | Hammer M; Brauser A; Olak C; Brezesinski G; Goldmann T; Gutsmann T; Andra J, Biochemical Journal, 2010

Phosphatidylglycerol is a widely used mimetic to study the effects of AMPs (antimicrobial peptides) on the bacterial cytoplasmic membrane. However, the antibacterial activities of novel NK-2-derived AMPs could not be sufficiently explained by using this simple model system. Since the LPS ...

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The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon

01-May-2010 | Sugiyama Y; Hatano N; Sueyoshi N; Suetake I; Tajima S; Kinoshita E; Kinoshita-Kikuta E; Koike T; Kameshita I, Biochemical Journal, 2010

Dnmt1 (DNA methyltansferase 1) is an enzyme that recognizes and methylates hemimethylated DNA during DNA replication to maintain methylation patterns. The N-terminal region of Dnmt1 is known to form an independent domain structure that interacts with various regulatory proteins and DNA. In the ...

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Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription

01-May-2010 | Zhang Y; Gao S; Wang Z, Biochemical Journal, 2010

We previously demonstrated that the Groucho protein AES (amino-terminal enhancer of split) functions as a co-repressor of the AR (androgen receptor). It physically interacts with the N-terminal domain of AR and inhibits AR-driven transcription, but the molecular mechanism of its action remained ...

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Disulfide formation in plant storage vacuoles permits assembly of a multimeric lectin

01-May-2010 | Marshall R; Frigerio L; Roberts L, Biochemical Journal, 2010

The ER (endoplasmic reticulum) has long been considered the plant cell compartment within which protein disulfide bond formation occurs. Members of the ER-located PDI (protein disulfide isomerase) family are responsible for oxidizing, reducing and isomerizing disulfide bonds, as well as ...

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Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes

01-May-2010 | Schrul B; Kapp K; Sinning I; Dobberstein B, Biochemical Journal, 2010

SPP (signal peptide peptidase) is an aspartyl intramembrane cleaving protease, which processes a subset of signal peptides, and is linked to the quality control of ER (endoplasmic reticulum) membrane proteins. We analysed SPP interactions with signal peptides and other membrane proteins by ...

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Co-segregation of AMPA receptors with GM1 ganglioside in synaptosomal membrane subfractions

01-May-2010 | Cole A; Dosemeci A; Reese T, Biochemical Journal, 2010

Biochemical studies have suggested that certain synaptic proteins associate with lipid rafts to perform key functions within the synapse. However, variability in biochemical preparations raises questions as to which synaptic proteins actually associate with lipid rafts. In the present study, we ...

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ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus

01-May-2010 | Papadopoulou V; Postigo A; Sanchez-Tillo E; Porter A; Wagner S, Biochemical Journal, 2010

BCL6 is essential for normal antibody responses and is highly expressed in germinal centre B-cells. Constitutive expression due to chromosomal translocations or mutations of cis-acting regulatory elements contributes to diffuse large B-cell lymphoma. BCL6 expression is therefore tightly regulated ...

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