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1,991 Newest Publications of Portland Press


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Arc is a flexible modular protein capable of reversible self-oligomerization

15-May-2015 | Myrum C; Baumann A; Bustad HJ; Flydal MI; Mariaule V; Alvira S; Cuellar J; Haavik J; Soule J; Valpuesta JM; Marquez ..., Biochemical Journal, 2015

The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties of Arc have not been elucidated. In the present study, we expressed and ...


An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

15-May-2015 | Irving JA; Miranda E; Haq I; Perez J; Kotov VR; Faull SV; Motamedi-Shad N; Lomas DA, Biochemical Journal, 2015

A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) ...


Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer

13-May-2015 | Babu E; Bhutia Y; Ramachandran S; Gnana-Prakasam J; Prasad P; Thangaraju M; Ganapathy V, Biochemical Journal, 2015

SLC6A14 mediates Na + /Cl --coupled concentrative uptake of a broad-spectrum of amino acids. It is expressed at low levels in many tissues but upregulated in certain cancers. Pharmacologic blockade of SLC6A14 causes amino acid starvation in ER+ breast cancer cells and suppresses their ...


The focal adhesion kinase Pyk2 links Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} signaling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

13-May-2015 | Canobbio I; Cipolla L; Guidetti G; Manganaro D; Visconte C; Kim S; Okigaki M; Falasca M; Kunapuli S; Torti M, Biochemical Journal, 2015

In blood platelets, stimulation of G protein-coupled receptors by thrombin triggers the activation of Src family kinases (SFKs), resulting in the tyrosine-phosphorylation of multiple substrates, but the mechanism underlying this process is still poorly understood. Here we show that the ...


Nuclear Cyclophilins Impact Spliceosome Assembly and Function {Less than}i{Greater than}In Vitro{Less than}/i{Greater than}

13-May-2015 | Adams B; Coates M; Jackson S; Jurica M; Davis T, Biochemical Journal, 2015

Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyze cis/trans isomerization of proline residues. There are seventeen annotated members of the cyclophilin family in humans, ubiquitously expressed and localized variously to the cytoplasm, nucleus, or ...


The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module

06-May-2015 | Maryati M; Airhihen B; Winkler G, Biochemical Journal, 2015

In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to its target mRNA by RNA-binding proteins or ...


Deciphering the unconventional peptide binding to the PDZ domain of MAST2

05-May-2015 | Delhommel F; Chaffotte A; Terrien E; Raynal B; Buc H; Delepierre M; Cordier F; Wolff N, Biochemical Journal, 2015

PTEN and MAST2 are key negative regulators of survival pathways in neuronal cells. The two proteins interact via the PDZ domain of MAST2 (MAST2-PDZ). During infection by rabies virus, the viral glycoprotein competes with PTEN for interaction with MAST2-PDZ and promotes neuronal survival. The ...


Acyl-CoA Binding Domain Containing 3 Modulates NAD{+} Metabolism through Activating Poly(ADP-ribose) Polymerase 1

05-May-2015 | Chen Y; Bang S; Park S; Shi H; Kim S, Biochemical Journal, 2015

Nicotinadmide adenine dinucleotide (NAD+) plays essential roles in cellular energy homeostasis and redox state functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD+-consuming enzymes, this molecule may be also involved ...


Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells {Less than}i{Greater than}ex vivo{Less than}/i{Greater than} through inhibition of {Less than}i{Greater than}de novo{Less than}/i{Greater than} lipogenesis

05-May-2015 | O'Brien A; Villani L; Broadfield L; Houde V; Galic S; Blandino G; Kemp B; Tsakaridis T; Muti P; Steinberg G, Biochemical Journal, 2015

Aspirin, the pro-drug of salicylate, is associated with reduced incidence of death from cancers of the colon, lung and prostate and is commonly prescribed in combination with metformin in individuals with type 2 diabetes. Salicylate activates the AMP-activated protein kinase (AMPK) by binding at ...


LRRK2 Dephosphorylation increases its ubiquitination.

05-May-2015 | Zhao J; Molitor T; Langston J; Nichols R, Biochemical Journal, 2015

Activating mutations in the LRRK2 gene are the most common cause of inherited Parkinson’s disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser910, 935, 955 and 973, which are dephosphorylated in several PD-related LRRK2 mutants [N1347H, R1441C/G, Y1699C and I2020T] ...


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