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Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP)

01-May-2010 | Schroder B; Saftig P, Biochemical Journal, 2010

The processing of membrane-anchored signalling molecules and transcription factors by RIP (regulated intramembrane proteolysis) is a major signalling paradigm in eukaryotic cells. Intramembrane cleaving proteases liberate fragments from membrane-bound precursor proteins which typically fulfil ...


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