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1,991 Newest Publications of Portland Press

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Structural and biochemical characterization of novel bacterial {alpha}-galactosidases belonging to glycoside hydrolase family 31

05-May-2015 | Miyazaki T; Ishizaki Y; Ichikawa M; Nishikawa A; Tonozuka T, Biochemical Journal, 2015

Glycoside hydrolase family 31 (GH31) proteins have been reportedly identified as exo-α-glycosidases with activity for α-glucosides and α-xylosides. We focused on a GH31 subfamily, which contains proteins with low sequence identity (8-barrel fold that resembles the structures of other GH31 ...

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The motor function of {Less than}i{Greater than}Drosophila melanogaster{Less than}/i{Greater than} myosin-5 is activated by calcium and cargo-binding protein dRab11

05-May-2015 | Ji H; Zhang H; Shen M; Yao L; Li X, Biochemical Journal, 2015

In the Drosophila melanogaster compound eye, myosin-5 (DmM5) plays two distinct roles in response to light stimulation: transport of pigment granules to the rhabdomere base to decrease light exposure and transport of rhodopsin-bearing vesicles to the rhabdomere base to compensate for the ...

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

01-May-2015 | Bulatov E; Ciulli A, Biochemical Journal, 2015

In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin-RING (really interesting new gene) ...

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The Two Component Signaling Networks of {Less than}i{Greater than}Mycobacterium tuberculosis{Less than}/i{Greater than} Displays Extensive Crosstalk {Less than}i{Greater than}In Vitro{Less than}/i{Greater than}

01-May-2015 | Agrawal R; Pandey A; Rajankar M; Dixit N; Saini D, Biochemical Journal, 2015

Two component systems (TCSs), which contain paired sensor kinase and response regulator proteins, form the primary apparatus for sensing and responding to environmental cues in bacteria. TCSs are thought to be highly specific, displaying minimal cross-talk, primarily due to the co-evolution of ...

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Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II

28-Apr-2015 | Ruggiero F; Vilcaes A; Iglesias-Bartolom{e} R; Daniotti J, Biochemical Journal, 2015

ST3Gal-II, a type II transmembrane protein, is the main mammalian sialyltransferase responsible for GD1a and GT1b ganglioside biosynthesis in brain. It contains two putative N-glycosylation sites (Asn92 and Asn211). While Asn92 is only conserved in mammalian species, Asn211 is highly conserved in ...

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Solution structure of the RNA-binding cold shock domain of the {Less than}i{Greater than}Chlamydomonas reinhardtii {Less than}/i{Greater than}NAB1 protein and insights into RNA recognition

28-Apr-2015 | Sawyer A; Landsberg M; Ross I; Kruse O; Mobli M; Hankamer B, Biochemical Journal, 2015

Light harvesting complex (LHC) proteins are among the most abundant proteins on Earth and play critical roles in photosynthesis, both in light capture and photoprotective mechanisms. The Chlamydomonas reinhardtii nucleic acid-binding protein 1 (NAB1) is a negative regulator of LHC protein ...

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Metabolomic profiling in liver of adiponectin knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action

27-Apr-2015 | Liu Y; Sen S; Wannaiampikul S; Palanivel R; Hoo R; Isserlin R; Bader G; Tungtrongchitr R; Deshaies Y; Xu A; Sweeney G, Biochemical Journal, 2015

Adiponectin mediates antidiabetic effects via increasing hepatic insulin sensitivity and direct metabolic effects. In this study we conducted a comprehensive and unbiased metabolomic profiling of liver tissue from adiponectin knockout (AdKO) mice, with and without adiponectin supplementation, fed ...

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Suppression of Interferon {beta} gene transcription by inhibitors of Bromodomain and Extra-Terminal (BET) family members

20-Apr-2015 | Malik N; Vollmer S; Nanda S; Lopez-Pelaez M; Prescott A; Gray N; Cohen P, Biochemical Journal, 2015

Polo-Like Kinase (PLK) inhibitors, such as BI-2536, have been reported to suppress interferon β (IFNβ) gene transcription induced by ligands that activate TLR3 and TLR4. Here, we report that BI-2536 is likely to exert this effect by preventing the interaction of the transcription factors IRF3 and ...

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Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

20-Apr-2015 | McGarry D; Chen W; Chakravarty P; Lamont D; Wolf C; Henderson C, Biochemical Journal, 2015

Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack the sensitivity to examine this modification ...

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