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42 Newest Publications about the topic animal testing


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Low cost bioluminescence imaging as an alternative to in vivo bioassays for quantifying biologically active staphylococcal enterotoxin type E

24-Dec-2017 | Author(s): Reuven Rasooly, Paula Do, Bradley J. Hernlem, Sensors and Actuators B: Chemical, 2017

Publication date: 15 April 2018 Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Reuven Rasooly, Paula Do, Bradley J. Hernlem Staphylococcus aureus is a major causative agent implicated in outbreaks of food poisoning. It acts through the production of a range of toxins ...


Revamp animal research rules, report urges

27-Oct-2017 | Warren Cornwall, Science , 2017

Scientists using animals in lab research are pressing the federal government to ease regulations. Several major organizations representing the scientists, universities, and private laboratories issued a report this week asking Congress, the White House, the U.S. Department of Agriculture, and the ...


Jaqpot Quattro: A Novel Computational Web Platform for Modeling and Analysis in Nanoinformatics

11-Sep-2017 | Charalampos Chomenidis; Georgios Drakakis; Georgia Tsiliki; Evangelia Anagnostopoulou; Angelos Valsamis; Philip Doga ..., Journal of Chemical Information and Modeling, 2017

Engineered nanomaterials (ENMs) are increasingly infiltrating our lives as a result of their applications across multiple fields. However, ENM formulations may result in the modulation of pathways and mechanisms of toxic action that endanger human health and the environment. Alternative testing ...


High-throughput identification of small molecules that affect human embryonic vascular development [Applied Biological Sciences]

11-Apr-2017 | Helena Vazão; Susana Rosa; Tânia Barata; Ricardo Costa; Patrícia R. Pitrez; Inês Honório; Margreet R. de Vries; Dimi ..., Proceedings of the National Academy of Sciences current issue, 2017

Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this ...


[In Depth] Failed spinal cord trial offers cautionary tale

17-Feb-2017 | Kelly Servick, Science , 2017

Eight months after cell therapy company StemCells Inc. announced the failure of its closely watched clinical trial for spinal cord injury, some of the company's longtime academic collaborators have come forward with disheartening animal data—and an admonition for future trials. Researchers at the ...


Using Chemical-Induced Gene Expression in Cultured Human Cells to Predict Chemical Toxicity

04-Nov-2016 | Ruifeng Liu; Xueping Yu; Anders Wallqvist, Chemical Research in Toxicology, 2016

Chemical toxicity is conventionally evaluated in animal models. However, animal models are resource intensive; moreover, they face ethical and scientific challenges because the outcomes obtained by animal testing may not correlate with human responses. To develop an alternative method for ...


What Happens after Activation of Ascaridole? Reactive Compounds and Their Implications for Skin Sensitization

24-Aug-2016 | Amar G. Chittiboyina; Cristina Avonto; Ikhlas A. Khan, Chemical Research in Toxicology, 2016

To replace animal testing and improve the prediction of skin sensitization, significant attention has been directed to the use of alternative methods. The direct peptide reactivity assay (DPRA), the regulatory agencies’ approved alternative in chemico method, has been applied for understanding ...


Organ‐on‐a‐Chip Systems: Microengineering to Biomimic Living Systems

22-Feb-2016 | Fuyin Zheng, Fanfan Fu, Yao Cheng, Chunyan Wang, Yuanjin Zhao, Zhongze Gu, Small, 2016

“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell–cell interactions, and extracellular microenvironments. This creative platform ...


IJMS, Vol. 17, Pages 256: Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells

19-Feb-2016 | Kawser Hossain, Mohammed ; Abdal Dayem, Ahmed ; Han, Jihae ; Kumar Saha, Subbroto ; Yang, Gwang-Mo ; Choi, Hye Yeon; ..., International Journal of Molecular Sciences, 2016

Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic patients remains limited. Although significant challenges remain, induced pluripotent stem cells (iPSCs) have the ...


Using Molecular Initiating Events to Develop a Structural Alert Based Screening Workflow for Nuclear Receptor Ligands Associated with Hepatic Steatosis

02-Feb-2016 | Claire L. Mellor; Fabian P. Steinmetz; Mark T. D. Cronin, Chemical Research in Toxicology, 2016

In silico models are essential for the development of integrated alternative methods to identify organ level toxicity and lead toward the replacement of animal testing. These models include (quantitative) structure–activity relationships ((Q)SARs) and, importantly, the identification of ...


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