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1,151 Newest Publications about the topic chemical synthesis


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The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

03-Jul-2018 | Yin-He Yang; Bin Di; Da-Song Yang, Organic & Biomolecular Chemistry, 2018

A counterintuitive freezing-induced peptide ligation was discovered in the total synthesis of human interferon-ε (hIFN-ε) which blocks HIV infection through unique mechanisms. The successful synthesis of hIFN-ε (187 amino acids) in this research laid the foundation for related anti-AIDS drug ...


Synthesis of Hydrophobic Insulin-based Peptides Using a Helping-Hand Strategy

26-Jun-2018 | Maria Disotuar; Mark E Petersen; Jason M Nogueira; Michael S Kay; Danny Hung-chieh Chou, Organic & Biomolecular Chemistry, 2018

The introduction of solid-phase peptide synthesis in the 1960’s improved the chemical synthesis of both the A- and B-chains of insulin and insulin analogs. However, the subsequent elaboration of the synthetic peptides to generate active hormones continues to be difficult and complex due in part ...


Plant extracts as green reductants for the synthesis of silver nanoparticles: Lessons from chemical synthesis

20-Jun-2018 | Muhammad Nawaz Nawaz Tahir; Mujeeb Khan; Mohammed Rafi Shaik; Syed Farooq Adil; Shams T. Khan; Abdulrahman Abdullah ..., Dalton Transactions, 2018

The increasing use of silver (Ag) nanoparticles (NPs) in daily-life applications, elec-tronics, or catalysis calls for green and cost-efficient synthetic methods. Ag NPs are used especially in biomedicine because of their antibacterial, antifungal or anticancer properties. The chemical synthesis ...


Room-temperature successive ion transfer chemical synthesis and the efficient acetone gas sensor and electrochemical energy storage applications of Bi2O3 nanostructures

20-Jun-2018 | Pritamkumar Shinde; Balaji Ghule; Nanasaheb M. Shinde; Qi xun Xia; Shoyeb Shaikh; Arvind Vishwanath Sarode; Rajaram ..., New Journal of Chemistry, 2018

Acetone gas sensor and electrochemical supercapacitor applications of bismuth oxide (Bi2O3) nanostructures unveiled using a facile and cost-effective quaternary-beaker wet chemical method on Soda-lime-glass (SLG) and Ni-foam substrates, respectively, are explored. As-deposited Bi2O3 on both ...


Xenoprotein engineering via synthetic libraries [Biophysics and Computational Biology]

05-Jun-2018 | Zachary P. Gates; Alexander A. Vinogradov; Anthony J. Quartararo; Anupam Bandyopadhyay; Zi-Ning Choo; Ethan D. Evans ..., Proceedings of the National Academy of Sciences current issue, 2018

Combinatorial protein libraries—prepared via molecular biology-based approaches—are invaluable tools for protein engineering. The inclusion of noncanonical amino acids in such libraries is of considerable interest. However, at present no approach competes with chemical synthesis in terms of the ...


Molecules, Vol. 23, Pages 1329: Red and Blue Light Promote the Accumulation of Artemisinin in Artemisia annua L.

31-May-2018 | Zhang, Dong ; Sun, Wei ; Shi, Yuhua ; Wu, Lan ; Zhang, Tianyuan ; Xiang, Li, Molecules, 2018

Molecules, Vol. 23, Pages 1329: Red and Blue Light Promote the Accumulation of Artemisinin in Artemisia annua L. Molecules doi: 10.3390/molecules23061329 Authors: Dong Zhang Wei Sun Yuhua Shi Lan Wu Tianyuan Zhang Li Xiang Artemisinin, which has been isolated from ...


Chemical synthesis of culmorin metabolites and their biologic role in culmorin and acetyl-culmorin treated wheat cells

30-May-2018 | Julia Weber; Marta Vaclavikova; Gerlinde Wiesenberger; Maximilian Haider; Christian Hametner; Johannes Fröhlich ..., Organic & Biomolecular Chemistry, 2018

The Fusarium metabolite culmorin (1) is receiving increased attention as an “emerging mycotoxin”. It co-occurs with trichothecene mycotoxins and potentially influences their toxicity. Its ecological role and fate in plants is unknown. We synthesized sulfated and glucosylated culmorin conjugates ...


Extended visible to near-infrared harvesting of earth-abundant FeS2–TiO2 heterostructures for highly active photocatalytic hydrogen evolution

26-May-2018 | Tsung-Rong Kuo; Hsiang-Ju Liao; Yu-Ting Chen; Chuan-Yu Wei; Chia-Che Chang; Yi-Chia Chen; Yi-Hsuan Chang; Jou-Chun L ..., Green Chemistry, 2018

Photocatalytic water splitting is a key technology for long-term hydrogen evolution with low environmental impact. In this work, an environment-friendly photocatalyst consisting of FeS2–TiO2 heterostructured nanocrystals has been successfully prepared by wet chemical synthesis for enhancing the ...


Against the rules: pressure induced transition from high to reduced order

25-May-2018 | Frederik Neuhaus; Dennis Mueller; Radu Tanasescu; Cristina Stefaniu; Pierre-Léonard Zaffalon; Sandor Balog; Tak ..., Soft Matter, 2018

Envisioning the next generation of drug delivery nanocontainers requires more in-depth information on the fundamental physical forces at play in bilayer membranes. In order to achieve this, we combine chemical synthesis with physical–chemical analytical methods and probe the relationship between ...


Sensors, Vol. 18, Pages 1620: A Tube-Integrated Painted Biosensor for Glucose and Lactate

18-May-2018 | Shi, Weihua ; Luo, Xiaojin ; Cui, Yue, Sensors, 2018

Sensors, Vol. 18, Pages 1620: A Tube-Integrated Painted Biosensor for Glucose and Lactate Sensors doi: 10.3390/s18051620 Authors: Weihua Shi Xiaojin Luo Yue Cui Developing a simple and direct approach for sensitive, specific, and rapid detection of metabolic compounds is of ...


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