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79 Newest Publications about the topic chiral hplc


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Molecules, Vol. 22, Pages 1413: Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

25-Aug-2017 | Shi, Yu-Sheng ; Zhang, Yan ; Hu, Wen-Zhong ; Zhang, Xiu-Fu ; Fu, Xin ; Lv, Xia, Molecules, 2017

Molecules, Vol. 22, Pages 1413: Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities Molecules doi: 10.3390/molecules22091413 Authors: Yu-Sheng Shi Yan Zhang Wen-Zhong Hu Xiu-Fu Zhang Xin Fu Xia Lv Two new dihydrochalcone enantiomers (+)-1 and ...


Racemic and enantiopure forms of 3‐ethyl‐3‐phenylpyrrolidin‐2‐one adopt very different crystal structures

11-Aug-2017 | Arcadius V. Krivoshein, Sergey V. Lindeman, Tatiana V. Timofeeva, Victor N. Khrustalev, Chirality, 2017

Abstract 3‐Ethyl‐3‐phenylpyrrolidin‐2‐one (EPP) is an experimental anticonvulsant based on the newly proposed α‐substituted amide group pharmacophore. These compounds show robust activity in animal models of drug‐resistant epilepsy and are thus promising for clinical development. In order to ...


Reliable HPLC separation, vibrational circular dichroism spectra, and absolute configurations of isoborneol enantiomers

15-Jul-2017 | Rui‐Qi Gao, Jun Fan, Qi Tan, Dong Guo, Tao Chen, Ru‐Jian He, Dan Li, Hui Zhang, Wei‐Guang Zhang, Chirality, 2017

Abstract Resolution of chiral compounds has played an important role in the pharmaceutical field, involving detailed studies of pharmacokinetics, physiological, toxicological, and metabolic activities of enantiomers. Herein, a reliable method by high‐performance liquid chromatography (HPLC) ...


Yttrium‐Benzyl Complexes Bearing Chiral Iminophosphonamide Ligands: Synthesis and Application in Catalytic Asymmetric Amine‐Silane Dehydrocoupling Reactions

11-Jul-2017 | Nan Li, Bing-Tao Guan, Advanced Synthesis & Catalysis, 2017

A series of novel iminophosphonamide ligands with chiral diamine moieties were designed and synthesized. Yttrium‐ benzyl compounds bearing these chiral iminophosphonamide ligands showed high reactivity and selectivity on the first catalytic asymmetric cross‐dehydrogenative coupling of amines ...


Synthesis, Resolution, and Absolute Configuration of Chiral Tris(2-pyridylmethyl)amine-Based Hemicryptophane Molecular Cages

30-May-2017 | Dawei Zhang; Benjamin Bousquet; Jean-Christophe Mulatier; Delphine Pitrat; Marion Jean; Nicolas Vanthuyne; Laure Guy ..., The Journal of Organic Chemistry, 2017

The synthesis, characterization, and chiroptical properties of a new class of hemicryptophane cages combining a cyclotriveratrylene unit and a tris(2-pyridylmethyl)amine (TPA) moiety are reported. Changing the linkers between these two units allows for the modification of the size and shape of ...


A Validated Enantioselective HPLC Method for Assay of S-Amlodipine Using Crown Ether as a Chiral Stationary Phase

18-May-2017 | M. Abdel-Megied, Ahmed; M. El-Gizawy, Samia; H. Abdelmageed, Osama; A. Omar, Mahmoud; M.Derayea, Sayed; Y. Aboul-Ene ..., Current Analytical Chemistry, 2017

Abstract: Background: Hypertension represents a widespread cardiovascular condition although usually asymptomatic, is a major risk factor for myocardial ischemia, renal failure and stroke. Amlodipine is considered a powerful dihydropyridine calcium channel blocker used as antihypertensive ...


Locking Interconversion of Aromatic Oligoamide Foldamers by Intramolecular Side‐chain Crosslinking: Toward Absolute Control of Helicity in Synthetic Aromatic Foldamers

17-Feb-2017 | Lu Zheng, Chengyuan Yu, Yulin Zhan, Xuebing Deng, Ying Wang, Hua Jiang, Chemistry - A European Journal, 2017

A series of foldamers of 8‐amino‐2‐quinolinecarboxylic acid were stapled by intramolecular ring‐closing olefin metathesis to generate the constrained aromatic foldamers with varying lengths of hydrocarbon side‐chains. Investigations clearly revealed that the side‐chain crosslinkers are capable ...


Chemoenzymatic preparation of enantiomerically enriched (R)‐(‐)‐mandelic acid derivatives: application in the synthesis towards the active agent pemoline

14-Feb-2017 | Paweł Borowiecki, Marcin Poterała, Maciej Dranka, European Journal of Organic Chemistry, 2017

The enantioselective resolutions of a several racemic derivatives of mandelic acid methyl ester catalyzed by lipases from Pseudomonas fluorescens (Amano AK) or Burkholderia cepacia (Amano PS‐C II and Amano PS‐IM) are demonstrated. A gram‐scale lipase‐mediated kinetic resolution approach have ...


“Inherently Chiral” Ionic‐Liquid Media: Effective Chiral Electroanalysis on Achiral Electrodes

18-Jan-2017 | Simona Rizzo, Serena Arnaboldi, Voichita Mihali, Roberto Cirilli, Alessandra Forni, Armando Gennaro, Abdirisak Ahmed ..., Angewandte Chemie International Edition, 2017

Abstract To achieve enantioselective electroanalysis either chiral electrodes or chiral media are needed. High enantiodiscrimination properties can be granted by the “inherent chirality” strategy of developing molecular materials in which the stereogenic element responsible for chirality ...


Five Pairs of Meroterpenoid Enantiomers from Rhododendron capitatum

12-Jan-2017 | Hai-Bing Liao; Guang-Hui Huang; Mei-Hua Yu; Chun Lei; Ai-Jun Hou, The Journal of Organic Chemistry, 2017

Chemical investigation on the aerial parts of Rhododendron capitatum resulted in the discovery of five enantiomeric pairs of new meroterpenoids, (+)-/(−)-rhodonoids C (1a and 1b), E (3a and 3b), F (4a and 4b), and (−)-/(+)-rhodonoids D (2a and 2b) and G (5a and 5b). These enantiomeric pairs ...


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