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167 Newest Publications about the topic combinatorial chemistry

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Bead-based screening in chemical biology and drug discovery

05-Jun-2018 | Katrine Qvortrup; Thomas Eiland Nielsen; Vitaly Komnatnyy, Chemical Communication, 2018

High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amanable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structural diverse ...

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Design and synthesis of novel monoterpenoid indole alkaloids-like analogues and their antitumour activities in vitro

29-May-2018 | Jiaqi Fang; Tao Huang; Mengyuan Xia; Lulu Deng; Xiaojiang Hao; Yuehu Wang; Shuzhen Mu, Organic & Biomolecular Chemistry, 2018

A biomimetic synthetic strategy and combinatorial chemistry were used to synthesize 34 novel monoterpenoid indole alkaloid (MIA) analogues, and their cytotoxic activities against five cancer cell lines (SW-480, A-549, HL-60, SMMC-7721, and MCF-7) were determined using the ...

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Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine

06-Oct-2017 | Leticia Monjas, Lotteke J. Y. M. Swier, Inda Setyawati, Dirk Jan Slotboom, Anna Katharina Herta Hirsch; Leticia M ..., ChemMedChem, 2017

Abstract We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S‐component of the energy‐coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre‐equilibrated dynamic combinatorial library (DCL) and saturation‐transfer difference (STD) NMR ...

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Selection of Effective HTRA3 Activators Using Combinatorial Chemistry

24-Aug-2017 | Magdalena Wysocka; Kamila Sychowska; Natalia Gruba; Łukasz Winiarski; Marcin Skoreński; Mateusz Psurski; Joanna Mako ..., Journal of Combinatorial Chemistry, 2017

Herein, we report selection, synthesis, and enzymatic evaluation of a peptidomimetic library able to increase proteolytic activity of HtrA3 (high temperature requirement A) protease. Iterative deconvolution in solution of synthesized modified pentapeptides yielded two potent HtrA3 activators ...

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Thiosemicarbazone Dynamic Combinatorial Chemistry: Equilibrator-Induced Dynamic State, Formation of Complex Libraries, and a Supramolecular On/Off Switch

03-Aug-2017 | Dennis Larsen; Anne Jeppesen; Claudia Kleinlein; Michael Pittelkow, The Journal of Organic Chemistry, 2017

Dynamic combinatorial libraries that equilibrate under thermodynamic control and can be trapped kinetically when desired are key to creating complex systems that can mimic dynamic biological systems, such as the biochemical system of life. A much-sought-after feature is the ability to turn off ...

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Thiosemicarbazone Dynamic Combinatorial Chemistry: Equilibrator-Induced Dynamic State, Formation of Complex Libraries, and a Supramolecular On/Off Switch

03-Aug-2017 | Dennis Larsen; Anne Jeppesen; Claudia Kleinlein; Michael Pittelkow, The Journal of Organic Chemistry, 2017

Dynamic combinatorial libraries that equilibrate under thermodynamic control and can be trapped kinetically when desired are key to creating complex systems that can mimic dynamic biological systems, such as the biochemical system of life. A much-sought-after feature is the ability to turn off ...

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Target‐directed dynamic combinatorial chemistry ‐ A study on potentials and pitfalls as exemplified on a bacterial target

28-Jun-2017 | Beat Ernst, Priska Frei, Lijuan Pang, Marleen Silbermann, Deniz Eris, Tobias Mühlethaler, Oliver Schwardt, Chemistry - A European Journal, 2017

Target‐directed dynamic combinatorial chemistry (DCC) is an emerging technique for the efficient identification of inhibitors of pharmacologically relevant targets. In this contribution, we present an application for a bacterial target, the lectin FimH, a crucial virulence factor of ...

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Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis

22-Jun-2017 | Dominik K. Kölmel; Eric T. Kool, Chemical Reviews, 2017

The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and ...

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Electrostatic Spray Ionization from 384-Well Microtiter Plates for Mass Spectrometry Analysis-Based Enzyme Assay and Drug Metabolism Screening

22-May-2017 | Liang Qiao; Xiaoqin Zhong; Emna Belghith; Yan Deng; Tzu-En Lin; Elena Tobolkina; Baohong Liu; Hubert H. Girault, Analytical Chemistry, 2017

We have realized the direct ionization of samples from wells of microtiter plates under atmospheric conditions for mass spectrometry analysis without any liquid delivery system or any additional interface. The microtiter plate is a commercially available 384-well plate without any modification, ...

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Molecules, Vol. 22, Pages 827: Highly Stereoselective Synthesis of a Compound Collection Based on the Bicyclic Scaffolds of Natural Products

18-May-2017 | Annamalai, Murali ; Hristeva, Stanimira ; Bielska, Martyna ; Ortega, Raquel ; Kumar, Kamal, Molecules, 2017

Despite the great contribution of natural products in the history of successful drug discovery, there are significant limitations that persuade the pharmaceutical industry to evade natural products in drug discovery research. The extreme scarcity as well as structural complexity of natural ...

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