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1,171 Newest Publications about the topic cross-couplingrss
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08-Sep-2017 | Michael G Organ, Gregory A Price, Abbas Hassan, Andrew R Bogdan, Stevan W Djuric, Angewandte Chemie International Edition, 2017
A silica‐supported precatalyst, Pd‐PEPPSI‐IPent‐SiO2 (7), has been prepared and evaluated for its proficiency in the Negishi cross‐coupling of hindered and electronically deactivated coupling partners. Precatalyst 7 loaded into packed bed columns has shown very high catalytic activity for the ...
10-Aug-2017 | Hu Zhang; Stephen L. Buchwald, Journal of the American Chemical Society, 2017
Journal of the American Chemical Society DOI: 10.1021/jacs.7b06630
12-Jul-2017 | Jesus Campos, Ainara Nova, Eugene L Kolychev, Simon Aldridge, Chemistry - A European Journal, 2017
Experimental and computational efforts are reported which illuminate the mechanism of a novel boron version of the widespread Negishi coupling reaction that offers a new protocol for the formation of aryl/acyl C‐B bonds using a bulky boryl fragment. The role of nucleophilic borylzinc reagents in ...
20-Jun-2017 | James D. Firth; Peter O’Brien; Leigh Ferris, The Journal of Organic Chemistry, 2017
To provide α-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic approach is required. Here, we report the development of two general and simple procedures for the racemic lithiation/trapping of N-Boc piperazines. Optimum lithiation times were ...
18-Apr-2017 | Simon Woodward, Miriam Ackermann, Saurabh Ahirwar, Laurence Burroughs, Mary Robert Garrett, John Ritchie, Jonathan S ..., Chemistry - A European Journal, 2017
A simple regiospecific route to otherwise problematic substituted tetracenes is described. The diverse cores (E)‐1,2‐Ar1CH2(HOCH2)C=C(CH2OH)I (Ar1 = Ph, 4‐MePh, 4‐MeOPh, 4‐FPh) and (E)‐1,2‐I(HOCH2)C=C(CH2OH)I, accessed from ultra‐low cost HOCH2C≡CCH2OH at multi‐gram scales, allow the synthesis ...
03-Mar-2017 | Michal Tichý; Sabina Smoleń; Eva Tloušt’ová; Radek Pohl; Tomáš Oždian; Klára Hejtmánková; Barbora Lišková; Soňa Gurs ..., Journal of Medicinal Chemistry, 2017
Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2′,3′:4,5]pyrrolo[2,3-d]pyrimidines and thieno[3′,2′:4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, ...
02-Feb-2017 | Naoki Miyagawa; Yuki Murase; Kentaro Okano; Atsunori Mori, Synlett, 2017
SynlettDOI: 10.1055/s-0036-1588142 A halogen dance of a benzoxazole-conjugated bromofuran derived from furfural is described. The reaction proceeds through a benzoxazole-directed lithiation to provide the α-lithiofuran, which is subjected to Negishi coupling to give α-arylated ...
03-Nov-2016 | Kallol Basu, Marc Poirier, Rebecca T. Ruck, ChemInform, 2016
Abstract The title transformation is achieved following a Negishi coupling protocol which tolerates variously functionalized aryl and hetaryl bromides.
26-Oct-2016 | Stéphanie Dupuy, Ke‐Feng Zhang, Anne‐Sophie Goutierre, Olivier Baudoin, Angewandte Chemie International Edition, 2016
Abstract Hydrocarbons are still the most important precursors of functionalized organic molecules, which has stirred interest in the discovery of new C−H bond functionalization methods. We describe herein a new step‐economical approach that enables C−C bonds to be constructed at the terminal ...
15-Sep-2016 | Kentaro Okano, Kazuhiro Sunahara, Yoshiki Yamane, Yuki Hayashi, Atsunori Mori, Chemistry - A European Journal, 2016
One‐pot halogen dance/Negishi cross coupling of readily available 2,5‐dibromothiophenes is described. An LDA‐mediated halogen dance reaction resulted in the formation of thermodynamically stable α‐lithiodibromothiophenes, which were transmetalated with ZnCl2 and subjected to Negishi cross ...