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1,171 Newest Publications about the topic cross-coupling


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Pd‐PEPPSI‐IPent‐SiO2, a Supported Catalyst for Challenging Negishi Coupling Reactions in Flow

08-Sep-2017 | Michael G Organ, Gregory A Price, Abbas Hassan, Andrew R Bogdan, Stevan W Djuric, Angewandte Chemie International Edition, 2017

A silica‐supported precatalyst, Pd‐PEPPSI‐IPent‐SiO2 (7), has been prepared and evaluated for its proficiency in the Negishi cross‐coupling of hindered and electronically deactivated coupling partners. Precatalyst 7 loaded into packed bed columns has shown very high catalytic activity for the ...


Palladium-Catalyzed Negishi Coupling of α-CF3 Oxiranyl Zincate: Access to Chiral CF3-Substituted Benzylic Tertiary Alcohols

10-Aug-2017 | Hu Zhang; Stephen L. Buchwald, Journal of the American Chemical Society, 2017

Journal of the American Chemical Society DOI: 10.1021/jacs.7b06630


A Combined Experimental/Computational Study of the Mechanism of a Palladium‐Catalyzed Bora‐Negishi Reaction

12-Jul-2017 | Jesus Campos, Ainara Nova, Eugene L Kolychev, Simon Aldridge, Chemistry - A European Journal, 2017

Experimental and computational efforts are reported which illuminate the mechanism of a novel boron version of the widespread Negishi coupling reaction that offers a new protocol for the formation of aryl/acyl C‐B bonds using a bulky boryl fragment. The role of nucleophilic borylzinc reagents in ...


General Procedures for the Lithiation/Trapping of N-Boc Piperazines

20-Jun-2017 | James D. Firth; Peter O’Brien; Leigh Ferris, The Journal of Organic Chemistry, 2017

To provide α-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic approach is required. Here, we report the development of two general and simple procedures for the racemic lithiation/trapping of N-Boc piperazines. Optimum lithiation times were ...


Straightforward Synthesis of 2‐ and 2,8‐Substituted Tetracenes

18-Apr-2017 | Simon Woodward, Miriam Ackermann, Saurabh Ahirwar, Laurence Burroughs, Mary Robert Garrett, John Ritchie, Jonathan S ..., Chemistry - A European Journal, 2017

A simple regiospecific route to otherwise problematic substituted tetracenes is described. The diverse cores (E)‐1,2‐Ar1CH2(HOCH2)C=C(CH2OH)I (Ar1 = Ph, 4‐MePh, 4‐MeOPh, 4‐FPh) and (E)‐1,2‐I(HOCH2)C=C(CH2OH)I, accessed from ultra‐low cost HOCH2C≡CCH2OH at multi‐gram scales, allow the synthesis ...


Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides

03-Mar-2017 | Michal Tichý; Sabina Smoleń; Eva Tloušt’ová; Radek Pohl; Tomáš Oždian; Klára Hejtmánková; Barbora Lišková; Soňa Gurs ..., Journal of Medicinal Chemistry, 2017

Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2′,3′:4,5]pyrrolo[2,3-d]pyrimidines and thieno[3′,2′:4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, ...


Benzoxazole-Directed Halogen Dance of Bromofuran

02-Feb-2017 | Naoki Miyagawa; Yuki Murase; Kentaro Okano; Atsunori Mori, Synlett, 2017

SynlettDOI: 10.1055/s-0036-1588142 A halogen dance of a benzoxazole-conjugated bromofuran derived from furfural is described. The reaction proceeds through a benzoxazole-directed lithiation to provide the α-lithiofuran, which is subjected to Negishi coupling to give α-arylated ...


ChemInform Abstract: Solution to the C3—Arylation of Indazoles: Development of a Scalable Method.

03-Nov-2016 | Kallol Basu, Marc Poirier, Rebecca T. Ruck, ChemInform, 2016

Abstract The title transformation is achieved following a Negishi coupling protocol which tolerates variously functionalized aryl and hetaryl bromides.


Terminal‐Selective Functionalization of Alkyl Chains by Regioconvergent Cross‐Coupling

26-Oct-2016 | Stéphanie Dupuy, Ke‐Feng Zhang, Anne‐Sophie Goutierre, Olivier Baudoin, Angewandte Chemie International Edition, 2016

Abstract Hydrocarbons are still the most important precursors of functionalized organic molecules, which has stirred interest in the discovery of new C−H bond functionalization methods. We describe herein a new step‐economical approach that enables C−C bonds to be constructed at the terminal ...


One‐pot Halogen Dance/Negishi Coupling of Dibromothiophenes for Regiocontrolled Synthesis of Multiply Arylated Thiophenes

15-Sep-2016 | Kentaro Okano, Kazuhiro Sunahara, Yoshiki Yamane, Yuki Hayashi, Atsunori Mori, Chemistry - A European Journal, 2016

One‐pot halogen dance/Negishi cross coupling of readily available 2,5‐dibromothiophenes is described. An LDA‐mediated halogen dance reaction resulted in the formation of thermodynamically stable α‐lithiodibromothiophenes, which were transmetalated with ZnCl2 and subjected to Negishi cross ...


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