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119 Newest Publications about the topic flow chemistry

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Catalytic Hydrogenation of N-4-nitrophenyl Nicotinamide in a Micro-Packed Bed Reactor

24-Jan-2018 | Cuixian Yang; Andrew R Teixeira,; Yanxiang Si; Stephen Born; Hongkun Lin; Yunfei Li Song; Maryam Peer; Benjamin M ..., Green Chemistry, 2018

Recent advancements in micro-flow technologies and a drive toward more efficient, greener and safer processes have led to aincreased focus on flow-chemistry for pharmaceutical production. In this work, we demonstrate the use of a stabilized Pd nanoparticle-organic-silica catalyst to selectively ...

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Continuous Flow Synthesis of Urea‐Containing Compound Libraries Based on the Piperidin‐4‐one Scaffold

20-Dec-2017 | Alejandra Riesco-Dominguez, Daniel Blanco-Ania, Floris P. J. T. Rutjes, European Journal of Organic Chemistry, 2017

The advantages of performing reactions in continuous flow versus the classic batch processes render flow chemistry a suitable technique for library synthesis. Inspired by our recent work to create fluorine‐containing N‐heterocycles and by the potential of the urea group in drug design, we ...

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Integration of Flow Chemistry in Multistep Syntheses

27-Nov-2017 | Thomas Wirth, European Journal of Organic Chemistry, 2017

Guest Editor Thomas Wirth gives a short introduction to the field of flow chemistry, in particular its use in multistep synthesis.

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Environment‐Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques

14-Aug-2017 | Róbert Örkényi, Gyula Beke, Eszter Riethmüller, Zoltán Szakács, János Kóti, Ferenc Faigl, János Éles, István Greiner, European Journal of Organic Chemistry, 2017

Flow chemistry proved to be a valuable technique to improve the discovery chemistry route to melanin‐concentrating hormone receptor 1 (MCHr1) antagonists with 1H,2H,3H,4H,5H‐[1,4]diazepino[1,7‐a]indole scaffold. Novel, one‐step heterogeneous catalytic hydrogenation for the synthesis of ethyl ...

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Environment‐Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques

14-Aug-2017 | Róbert Örkényi, Gyula Beke, Eszter Riethmüller, Zoltán Szakács, János Kóti, Ferenc Faigl, János Éles, István Greiner, European Journal of Organic Chemistry, 2017

Flow chemistry proved to be a valuable technique to improve the discovery chemistry route to melanin‐concentrating hormone receptor 1 (MCHr1) antagonists with 1H,2H,3H,4H,5H‐[1,4]diazepino[1,7‐a]indole scaffold. Novel, one‐step heterogeneous catalytic hydrogenation for the synthesis of ethyl ...

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Flow Asymmetric Propargylation: Development of Continuous Processes for a Chiral beta‐Amino Alcohol

15-Jun-2017 | Yuan-Qing Fang, Hui Li, Jillian W Sheeran, Andrew M Clausen, Matthew M Bio, Scott Bader, Angewandte Chemie International Edition, 2017

The development of a flow chemistry process for asymmetric propargylation using allene gas as a reagent is reported. The connected continuous process of allene dissolution, lithiation, Li‐Zn transmetallation and asymmetric propargylation provides homopropargyl ‐amino alcohol 1 with high regio‐ ...

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Segmented Flow Platform for On-Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets

06-Jun-2017 | Ye-Jin Hwang; Connor W Coley; Milad Abolhasani; Andreas Marzinzik; Guido Koch; Carsten Spanka; Hansjoerg Lehmann; ..., Chemical Communication, 2017

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 uL. The breadth of compatible chemistries are demonstrated on common medicinal chemistry transformations ...

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The Hitchhiker’s Guide to Flow Chemistry∥

01-Jun-2017 | Matthew B. Plutschack; Bartholomäus Pieber; Kerry Gilmore; Peter H. Seeberger, Chemical Reviews, 2017

Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask. Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions. This relatively young technology ...

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From Ligand to Phosphor: Rapid, Machine‐Assisted Syntheses of Substituted Iridium(III)‐Pyrazolate Complexes with Tuneable Luminescence

22-May-2017 | Simon J. Pope, Lara Groves, Christiane Schotten, Joseph Beames, James Platts, Duncan Browne, Simon Coles, Peter Horton, Chemistry - A European Journal, 2017

A first generation machine‐assisted approach towards the preparation of hybrid ligand/metal materials has been explored. A comparison of synthetic approaches demonstrates that incorporation of both flow chemistry and microwave heating, can be successfully applied to the rapid synthesis of a ...

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Opening of new synthetic routes using segmented micro flow in multistep syntheses

21-Mar-2017 | Dominik Karl, Pia Börner, Viktor Misuk, Holger Löwe, Chemical Engineering & Technology, 2017

Abstract The application of microfluidics in organic chemistry is a valuable tool to access new synthesis pathways and to break limitations set by traditional batch chemistry. In the past, the majority of research focused on solving problems associated with individual reactions. It is ...

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