My watch list
my.chemeurope.com  
Login  

34 Newest Publications about the topic high throughput experimentation

rss

You can refine your search further. Select from the filter options on the left to narrow down your results.

Ligand libraries for high throughput screening of homogeneous catalysts

27-May-2018 | Marc Renom-Carrasco; Laurent Lefort, Chemical Society Reviews, 2018

To accelerate the discovery of new or improved homogeneous catalysts, research groups in industry and academia have embraced high throughput experimentation (HTE). Such methodologies consist of preparing and testing large numbers of catalysts in parallel. Homogeneous metal catalysts are very ...

more

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

02-Mar-2017 | Tim Cernak; Nathan J. Gesmundo; Kevin Dykstra; Yang Yu; Zhicai Wu; Zhi-Cai Shi; Petr Vachal; Donald Sperbeck; Shuwen ..., Journal of Medicinal Chemistry, 2017

Miniaturization and parallel processing play an important role in the evolution of many technologies. We demonstrate the application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the frontlines of a lead optimization effort to develop ...

more

High Throughput Light Absorber Discovery, Part 1: An Algorithm for Automated Tauc Analysis

13-Oct-2016 | Santosh K. Suram; Paul F. Newhouse; John M. Gregoire, Journal of Combinatorial Chemistry, 2016

High-throughput experimentation provides efficient mapping of composition–property relationships, and its implementation for the discovery of optical materials enables advancements in solar energy and other technologies. In a high throughput pipeline, automated data processing algorithms are ...

more

Feedback in Flow for Accelerated Reaction Development

15-Aug-2016 | Brandon J. Reizman; Klavs F. Jensen, Accounts of Chemical Research, 2016

ConspectusThe pharmaceutical industry is investing in continuous flow and high-throughput experimentation as tools for rapid process development accelerated scale-up. Coupled with automation, these technologies offer the potential for comprehensive reaction characterization and optimization, but ...

more

Nickel Catalysts for the Dehydrative Decarbonylation of Carboxylic Acids to Alkenes

12-Jul-2016 | Alex John; Maria O. Miranda; Keying Ding; Büsra Dereli; Manuel A. Ortuño; Anne M. LaPointe; Geoffrey W. Coates; Chri ..., Organometallics, 2016

Combining high-throughput experimentation with conventional experiments expedited discovery of new first-row nickel catalysts for the dehydrative decarbonylation of the bioderived substrates hydrocinnamic acid and fatty acids to their corresponding alkenes. Conventional experiments using a ...

more

Nickel-Catalyzed Asymmetric Alkene Hydrogenation of α,β-Unsaturated Esters: High-Throughput Experimentation-Enabled Reaction Discovery, Optimization, and Mechanistic Elucidation

02-Mar-2016 | Michael Shevlin; Max R. Friedfeld; Huaming Sheng; Nicholas A. Pierson; Jordan M. Hoyt; Louis-Charles Campeau; Paul J ..., Journal of the American Chemical Society, 2016

A highly active and enantioselective phosphine-nickel catalyst for the asymmetric hydrogenation of α,β-unsaturated esters has been discovered. The coordination chemistry and catalytic behavior of nickel halide, acetate, and mixed halide-acetate with chiral bidentate phosphines have been explored ...

more

Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates

25-Jan-2016 | Melodie Christensen; Andrew Nolting; Michael Shevlin; Mark Weisel; Peter E. Maligres; Joshua Lee; Robert K. Orr; Chr ..., The Journal of Organic Chemistry, 2016

α- and β-substitution of dihydrocinnamates has been shown to increase the biological activity of various drug candidates. Recently, we identified enantio- and diastereopure α-methyl-β-cyclopropyldihydrocinnamates to be important pharmacophores in one of our drug discovery programs and endeavored ...

more

A Fluorescence‐Based Screening Protocol for the Identification of Water Oxidation Catalysts

04-Sep-2015 | Remko J. Detz, Zohar Abiri, Alexander M. Kluwer, Joost N. H. Reek, ChemSusChem, 2015

Abstract Efficient catalysts are crucial for the sustainable generation of fuel by splitting water. A versatile screening protocol would simplify the identification of novel and better catalysts by using high throughput experimentation. Herein, such a screening approach for the identification ...

more

Highly customisable scanning droplet cell microscopes using 3D-printing

01-Feb-2015 | Author(s): Jan Philipp Kollender , Michael Voith , Simon Schneiderbauer , Andrei Ionut Mardare , Achim Walter H ..., Journal of Electroanalytical Chemistry, 2015

Publication date: 1 March 2015 Source:Journal of Electroanalytical Chemistry, Volume 740 Author(s): Jan Philipp Kollender , Michael Voith , Simon Schneiderbauer , Andrei Ionut Mardare , Achim Walter Hassel 3D printing was applied for the first time to produce highly customised flow ...

more

High-Throughput Investigation of Catalysts for JP-8 Fuel Cracking to Liquefied Petroleum Gas

06-Aug-2013 | John E. Bedenbaugh; Sungtak Kim; Erdem Sasmaz; Jochen Lauterbach, Journal of Combinatorial Chemistry, 2013

Portable power technologies for military applications necessitate the production of fuels similar to LPG from existing feedstocks. Catalytic cracking of military jet fuel to form a mixture of C2–C4 hydrocarbons was investigated using high-throughput experimentation. Cracking experiments were ...

more

Page 1 From 4
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE