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26 Newest Publications about the topic lc columns


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Comparison of fully‐wettable RPLC stationary phases for LC‐MS‐based cellular metabolomics

10-Jul-2017 | Le Si‐Hung, Tim J. Causon, Stephan Hann, ELECTROPHORESIS, 2017

Reversed‐phase LC combined with high‐resolution mass spectrometry (HRMS) is one of the most popular methods for cellular metabolomics studies. Due to the difficulties in analysing a wide range of polarities encountered in the metabolome, 100%‐wettable reversed‐phase materials are frequently used ...


Separation of Ellagitannin-Rich Phenolics from U.S. Pecans and Chinese Hickory Nuts Using Fused-Core HPLC Columns and Their Characterization

03-Jul-2017 | Yi Gong; Ronald B. Pegg, Journal of Agricultural and Food Chemistry, 2017

U.S. pecans and Chinese hickory nuts possess a wide array of phenolic constituents with potential health benefits including phenolic acids and proanthocyanidins. Only limited information is available, however, on their compositions. The present study optimized the separation performance and ...


Graphical Data Representation Methods To Assess the Quality of LC Columns

21-May-2015 | Gert Desmet; Deirdre Cabooter; Ken Broeckhoven, Analytical Chemistry, 2015

Analytical Chemistry DOI: 10.1021/ac504473p


Tandem LC columns for the simultaneous retention of polar and non‐polar molecules in comprehensive metabolomics analysis

09-Sep-2013 | Kenneth R. Chalcraft, Brian E. McCarry, Journal of Separation Science, 2013

Abstract The tandem use of hydrophilic interaction liquid chromatography columns with reversed phase columns in series configuration has resulted in the retention of both polar and non‐polar components in complex biological samples (mouse serum) in a single analysis. This approach successfully ...


Identification of Conjugated Linoleic Acid (CLA) Isomers by Silver Ion-Liquid Chromatography/In-line Ozonolysis/Mass Spectrometry (Ag+-LC/O3-MS)

10-Jul-2013 | Chenxing Sun; Brenna A. Black; Yuan-Yuan Zhao; Michael G. Gänzle; Jonathan M. Curtis, Analytical Chemistry, 2013

A novel method for the identification of conjugated linoleic acid (CLA) isomers has been developed in which silver ion liquid chromatography is coupled to in-line ozonolysis/mass spectrometry (Ag+-LC/O3-MS). The mobile phase containing CLA isomers eluting from the Ag+-LC column flows through a ...


A High Sample Throughput LC–GC Method for Mineral Oil Determination

09-Jul-2013 | Laura Barp, Giorgia Purcaro, Sabrina Moret, Lanfranco S. Conte, Journal of Separation Science, 2013

The present investigation deals with a method improvement to increase data throughput and reduce solvent consumption for mineral oil determination (both saturated and aromatic hydrocarbons in mineral oil) using a coupled LC–GC system. The starting point of this work was the method proposed by ...


Strategies for ascertaining the interference of phase II metabolites co‐eluting with parent compounds using LC–MS/MS

12-Jun-2013 | Caiming Tang, Caixing Tang, Wei Zhan, Juan Du, Zhifang Wang, Xianzhi Peng, Journal of Separation Science, 2013

LC–MS/MS is currently the most selective and efficient tool for the quantitative analysis of drugs and metabolites in the pharmaceutical industry and in clinical assays. However, phase II metabolites sometimes negatively affect the selectivity and efficiency of the LC–MS/MS method, especially ...


Analysis of Selected Sugars and Sugar Phosphates in Mouse Heart Tissue by Reductive Amination and Liquid Chromatography-Electrospray Ionization Mass Spectrometry

30-May-2013 | Jun Han; Vera Tschernutter; Juncong Yang; Tobias Eckle; Christoph H. Borchers, Analytical Chemistry, 2013

Sensitive and reliable analysis of sugars and sugar phosphates in tissues and cells is essential for many biological and cell engineering studies. However, the successful analysis of these endogenous compounds in biological samples by liquid chromatography/electrospray ionization mass ...


Liquid Chromatography, Chemical Oxidation, and Online Carbon Isotope Dilution Mass Spectrometry as a Universal Quantification System for Nonvolatile Organic Compounds

07-Jan-2013 | Sergio Cueto Díaz; Jorge Ruiz Encinar; Alfredo Sanz-Medel; J. Ignacio García Alonso, Analytical Chemistry, 2013

A procedure for the universal detection and quantification of polar organic compounds separated by liquid chromatography (LC) based on postcolumn carbon isotope dilution mass spectrometry (IDMS) was developed. The eluent from the LC column is mixed online with a continuous flow of 13C-enriched ...


Improved ruggedness of an ion‐pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells

26-Dec-2012 | Yue Zhao, Guowen Liu, Yifei Liu, Long Yuan, Dara Hawthorne, Jim X. Shen, Mausumee Guha, Anne Aubry, Rapid Communications in Mass Spectrometry, 2012

RATIONALE Nucleotide analogs are highly polar and ionic, which impose great challenges on bioanalysis. Ion‐pairing liquid chromatography/tandem mass spectrometry (LC/MS/MS) is the predominant reported approach for such compounds. Assay ruggedness of ion‐pairing LC/MS/MS methods was often a ...


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