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250 Newest Publications about the topic maldi mass spectrometry


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Concomitant desalting and concentration of neuropeptides on a donut-shaped surface pattern for MALDI mass spectrometry

24-May-2018 | Sook Yoon; Sanghwan Park; Min Sun Kim; Chang Young Lee, Chemical Communication, 2018

We demonstrate that a donut-shaped surface pattern consisting of a central hydrophobic region and a surrounding hydrophilic region simultaneously concentrates and desalts a solution of neuropeptides with a high salt content. Our approach greatly simplifies the sample preparation process for MALDI ...


New Insights into the Wavelength Dependence of MALDI Mass Spectrometry

05-Jul-2017 | Marcel Niehaus; Andreas Schnapp; Annika Koch; Jens Soltwisch; Klaus Dreisewerd, Analytical Chemistry, 2017

The interplay between the wavelength of the laser and the absorption profile of the matrix constitutes a crucial factor in matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). Numerous studies have shown that typically best analytical results are obtained if the laser ...


An update on MALDI mass spectrometry based technology for the analysis of fingermarks – stepping into operational deployment

28-Jun-2017 | S. Francese; R. Bradshaw; N. Denison, Analyst, 2017

Since 2009, when Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging (MALDI MSI) was firstly reported for the molecular mapping of latent fingermarks, the range of information and operational capabilities have steadily increased. Pioneering work from our Fingermark Research ...


Hexagonal boron nitride nanosheets as a multifunctional background-free matrix to detect small molecules and complicated samples by MALDI mass spectrometry

21-Jun-2017 | Jianing Wang; Jie Sun; Jiyun Wang; Huihui Liu; Jinjuan Xue; Zongxiu Nie, Chemical Communication, 2017

Here we report the innovation of using hexagonal boron nitride (h-BN) nanosheets as the first background-free matrix among the full laser pulse energy range for the analysis and imaging of small molecule metabolites and as an adsorbent for the enrichment of samples. Due to its totally free ...


Chemoselective ligation reaction of N-acetylglucosamine (NAG) with hydrazide functional probes to determine galactosyltransferase activity by MALDI mass spectrometry

23-May-2017 | Quan Cheng; Hyojik Yang, Analyst, 2017

Quantitation of β-1,4-galactosyltransferase (β-1,4-GT) activity is of considerable significance in the diagnosis of various cancers including lung and ovarian cancer. We report here the use of synthetic β-N-acetylglucosamine (NAG) ligands that contain hydrazide functional groups to determine ...


Step by Step Assembly of Polynuclear Lanthanide Complexes with a Phosphonated Bipyridine Ligand

05-Dec-2016 | Nabila Souri; Pingping Tian; Alexandre Lecointre; Zoé Lemaire; Salah Chafaa; Jean-Marc Strub; Sarah Cianférani; Mour ..., Inorganic Chemistry, 2016

The synthesis of the octadentate ligand L (LH8 = ((([2,2′-bipyridine]-6,6′-diylbis(methylene))bis(azanetriyl))tetrakis(methylene))tetrakis(phosphonic acid)) is reported. The coordination of L with various lanthanide cations was monitored by absorption and luminescence spectrophotometric titration ...


Protein Chips Compatible with MALDI Mass Spectrometry Prepared by Ambient Ion Landing

12-Aug-2016 | Petr Pompach; Oldřich Benada; Michal Rosůlek; Petra Darebná; Jiří Hausner; Viktor Růžička; Michael Volný; Petr Novák, Analytical Chemistry, 2016

We present a technology that allows the preparation of matrix-assisted laser desorption/ionization (MALDI)-compatible protein chips by ambient ion landing of proteins and successive utilization of the resulting protein chips for the development of bioanalytical assays. These assays are based on ...


A one‐step matrix application method for MALDI mass spectrometry imaging of bacterial colony biofilms

01-Aug-2016 | Bin Li, Troy J. Comi, Tong Si, Sage J. B. Dunham, Jonathan V. Sweedler, Journal of Mass Spectrometry, 2016

MALDI imaging of biofilms cultured on agar plates is challenging because of problems related to matrix deposition onto agar. We describe a one‐step, spray‐based application of a 2,5‐dihydroxybenzoic acid solution for direct MALDI imaging of hydrated Bacillus subtilis biofilms on agar. Using both ...


The quest for improved reproducibility in MALDI mass spectrometry

16-Jul-2016 | Matthew B. O'Rourke, Steven P. Djordjevic, Matthew P. Padula, Mass Spectrometry Reviews, 2016

Reproducibility has been one of the biggest hurdles faced when attempting to develop quantitative protocols for MALDI mass spectrometry. The heterogeneous nature of sample recrystallization has made automated sample acquisition somewhat “hit and miss” with manual intervention needed to ensure ...


Mass Barcode Signal Amplification for Multiplex Allergy Diagnosis by MALDI-MS

08-Jun-2016 | Xiaoqin Zhong; Liang Qiao; Natalia Gasilova; Baohong Liu; Hubert H. Girault, Analytical Chemistry, 2016

A highly sensitive method based on mass-barcoded gold nanoparticles (AuNPs) and immunomagnetic separation has been developed for multiplex allergy diagnosis by MALDI mass spectrometry in a component-resolved manner. Different analytical probes were prepared by coating AuNPs with individual ...


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