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181 Newest Publications about the topic mechanochemistry


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Mechanochemistry for “no solvent, no base” preparation of Hydantoin-based Active Pharmaceutical Ingredients: Nitrofurantoin and Dantrolene.

12-Jun-2018 | Evelina Colacino; Andrea Porcheddu; Ivan Halasz; Clarence Charnay; Francesco Delogu; Ruben Guerra; Julien Fullenwarth, Green Chemistry, 2018

The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as Nitrofurantoin (Furantin©), Dantrolene (Dantrium©) and their structurally related derivatives, is herein reported. Not a drop of organic solvent ...


Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing

29-May-2018 | Adam A. L. Michalchuk; Karl S. Hope; Stuart R. Kennedy; Maria V. Blanco; Elena V. Boldyreva; Colin R. Pulham, Chemical Communication, 2018

Resonant acoustic mixing (RAM) is a new technology designed for intensive mixing of powders that offers the capability to process powders with minimal damage to particles. This feature is particularly important for mixing impact-sensitive materials such as explosives and propellants. While the ...


Orthogonality in main group compounds: a direct one-step synthesis of air- and moisture-stable cyclophosphazanes by mechanochemistry

28-May-2018 | Ying Sim; Davin Tan; Rakesh Ganguly; Yongxin Li; Felipe García, Chemical Communication, 2018

Mechanochemistry has been established to be an environmentally-friendly way of conducting reactions in a solvent-free manner. The development of mechanochemical orthogonal reactions, in which multiple reagents are milled together, can be a powerful strategy to selectively yield the desired ...


Mechanochemistry and organic synthesis: from mystical to practical

25-May-2018 | J. Andersen; J. Mack, Green Chemistry, 2018

Perhaps due in no small part to its historical mystique, mechanochemistry has been shrowded in relative obscurity for quite some time. The successes of mechanochemistry in organic synthesis have often been curtailed by a fundamentally limited mechanistic understanding. Lately, however, the ...


Mechanochemistry – a new powerful green approach to the direct synthesis of alkoxysilanes

25-May-2018 | Maxim N. Temnikov; Anton A. Anisimov; Pavel V. Zhemchugov; Dmitry N. Kholodkov; Alexander S. Goloveshkin; Alexander ..., Green Chemistry, 2018

The present work shows a new one-stage mechanochemical method for the direct synthesis of alkoxysilanes by silicon mechanoactivation followed by a reaction with an alcohol. Alkoxysilanes were obtained with nearly complete silicon and alcohol conversion. This method allows for a considerable ...


Mechanochemistry and cocrystallization of 3-iodoethynylbenzoic acid with nitrogen-containing heterocycles: concurrent halogen and hydrogen bonding

23-May-2018 | Patrick M. J. Szell; Julien Dragon; Scott Zablotny; Stephen R. Harrigan; Bulat Gabidullin; David L. Bryce, New Journal of Chemistry, 2018

Halogen bonding has been shown to be a versatile interaction for crystal engineering purposes, with characteristics that parallel those of hydrogen bonding. Here, we explore the potential of a new halogen bond donor, 3-iodoethynylbenzoic acid (1), which is functionalized with both halogen bond ...


Oxidative mechanochemistry for direct, room‐temperature, solvent‐free conversion of palladium and gold metals into soluble salts and coordination complexes

18-Jan-2018 | Jean-Louis Do, Davin Tan, Tomislav Friscic, Angewandte Chemie International Edition, 2018

Noble metals are valued critical elements whose chemical activation or recycling is challenging, traditionally requiring high temperatures, strong acids or bases, or aggressive complexation agents. Using elementary palladium and gold, we demonstrate mechanochemistry for noble metal activation ...


Solvent‐free enzyme activity: quick, high‐yielding mechano‐enzymatic hydrolysis of cellulose into glucose

17-Jan-2018 | Fabien Hammerer, Leigh Loots, Jean-Louis Do, J. P. Daniel Therien, Christopher W. Nickels, Tomislav Friscic, Karine ..., Angewandte Chemie International Edition, 2018

Mechanochemistry enables enzymatic cleavage of cellulose into glucose without bulk solvents, acids, other aggressive reagents or substrate pre‐treatment. This clean mechano‐enzymatic process is also directly applicable to biomass, avoids many limitations associated with the use of cellulases, ...


High Throughput Mechanochemistry: Application to Parallel Synthesis of Benzoxazines

10-Jan-2018 | Katia Martina; Laura Rotolo; Andrea Porcheddu; Francesco Delogu; Stephen Bysouth; Giancarlo Cravotto; Evelina Colacino, Chemical Communication, 2018

We describe herein an unprecedented mechanochemical “parallel synthesis” of 3,4-dihydro-2H-benzo[e][1,3]oxazine derivatives via a one pot three component reaction. The new milling system uses a multiposition jar (variable sizes are possible), allowing to process up to 12 samples simultaneously, ...


Cover Feature: Mechanochemistry for Organic Chemists: An Update (Eur. J. Org. Chem. /2018)

18-Dec-2017 | Davin Tan, Tomislav Friščić, European Journal of Organic Chemistry, 2017

The Cover Feature shows the scope and diversity of modern mechanochemical organic synthesis. Over the past decade, mechanochemical reactions conducted by milling, grinding, or other types of impact and shear have evolved into a powerful solvent‐free alternative to conventional solution ...


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