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1,186 Newest Publications about the topic oligonucleotides

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Molecules, Vol. 23, Pages 1515: Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

22-Jun-2018 | Flamme, Marie ; Clarke, Emma ; Gasser, Gilles ; Hollenstein, Marcel, Molecules, 2018

Molecules, Vol. 23, Pages 1515: Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives Molecules doi: 10.3390/molecules23071515 Authors: Marie Flamme Emma Clarke Gilles Gasser Marcel Hollenstein Oligonucleotides are biopolymers that can be easily ...

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A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus [Medical Sciences]

19-Jun-2018 | Daniela Castanotto; Xiaowei Zhang; Jessica Alluin; Xizhe Zhang; Jacqueline Rüger; Brian Armstrong; John Rossi; Arthu ..., Proceedings of the National Academy of Sciences current issue, 2018

The deregulation of miRNA function is critical in the pathogenesis of cancer and other diseases. miRNAs and other noncoding RNAs (ncRNAs) tightly regulate gene expression, often in the cell nucleus. Heretofore, there has been no understanding that there exists a general shuttling mechanism that ...

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Protected 2'-deoxyribonucleoside triphosphate building blocks for photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA

12-Jun-2018 | Sona Bohacova; Zuzana Vanikova; Lenka Slavetinska; Michal Hocek, Organic & Biomolecular Chemistry, 2018

2'-Deoxyribonucleoside triphosphates (dNTPs) containing 5-(hydroxymethyl)cytosine (5hmC) protected with photocleavable groups (2-nitrobenzyl or 6-nitropiperonyl) groups were prepared and studied as substrates for enzymatic synthesis of oligonucleotides and DNA containing photocaged epigenetic ...

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XNA ligation using T4 DNA ligase in crowding conditions

06-Jun-2018 | Donaat Kestemont; Marleen Renders; Piotr Leonczak; Michael Abramov; Guy Schepers; Vitor Bernardes Pinheiro; Jef Roze ..., Chemical Communication, 2018

T4 DNA ligase is capable of ligating 2’OMe-RNA duplexes, HNA, LNA and FANA mixed sequences in the presence of 10% w/v PEG8000 and 3 M betaine. The enzymatic joining of oligonucleotides containing multiple consecutive XNA nucleotides at the ligation site has not been reported before.

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Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA

01-Jun-2018 | Soňa Boháčová; Lucie Ludvíková; Lenka Poštová Slavětínská; Zuzana Vaníkov ..., Organic & Biomolecular Chemistry, 2018

Nucleosides, nucleotides and 2′-deoxyribonucleoside triphosphates (dNTPs) containing 5-(hydroxymethyl)uracil protected with photocleavable groups (2-nitrobenzyl-, 6-nitropiperonyl or 9-anthrylmethyl) were prepared and tested as building blocks for the polymerase synthesis of photocaged ...

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Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA

01-Jun-2018 | Soňa Boháčová; Lucie Ludvíková; Lenka Poštová Slavětínská; Zuzana Vaníkov ..., Organic & Biomolecular Chemistry, 2018

Nucleosides, nucleotides and 2′-deoxyribonucleoside triphosphates (dNTPs) containing 5-(hydroxymethyl)uracil protected with photocleavable groups (2-nitrobenzyl-, 6-nitropiperonyl or 9-anthrylmethyl) were prepared and tested as building blocks for the polymerase synthesis of photocaged ...

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Theoretical Insights into the Structural and Fluorescence Properties of DNA Containing Fluorescent Nucleobases

01-Jun-2018 | Wenjuan Wang; Xiehuang Sheng; Shaolong Zhang; Fang Huang; Chuanzhi Sun; Jian-Biao Liu; Dezhan Chen, Physical Chemistry Chemical Physics, 2018

Fluorescent base analogues are of great importance as sensitive probes to detect the dynamic structures of DNA. Herein, we characterized the structural and photophysical properties of 13-mer oligonucleotides containing 4AP:DAP (4AP0, 4AP‘), employing both molecular dynamics simulations and ...

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Theoretical Insights into the Structural and Fluorescence Properties of DNA Containing Fluorescent Nucleobases

01-Jun-2018 | Wenjuan Wang; Xiehuang Sheng; Shaolong Zhang; Fang Huang; Chuanzhi Sun; Jian-Biao Liu; Dezhan Chen, Physical Chemistry Chemical Physics, 2018

Fluorescent base analogues are of great importance as sensitive probes to detect the dynamic structures of DNA. Herein, we characterized the structural and photophysical properties of 13-mer oligonucleotides containing 4AP:DAP (4AP0, 4AP‘), employing both molecular dynamics simulations and ...

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Modeling of canonical and C2[prime or minute]-O-thiophenylmethyl modified hexamers of RNA. Insights into the nature of structural changes and thermal stability

30-May-2018 | Yannick Kokouvi Dzowo; Carly Wolfbrandt; Marino J. E. Resendiz; Haobin Wang, New Journal of Chemistry, 2018

Modifying the ribose ring or the nucleobase within oligonucleotides of RNA is a strategy that has regained attention due to its potential to provide chemical stability, increase affinity towards a target, or introduce groups with bioorthogonal reactivity, among other applications. However ...

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Molecules, Vol. 23, Pages 1302: A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey

29-May-2018 | Oberemok, Volodymyr V.; Laikova, Kateryna V.; Repetskaya, Anna I.; Kenyo, Igor M.; Gorlov, Mikhail V.; Kasich, ..., Molecules, 2018

Molecules, Vol. 23, Pages 1302: A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey Molecules doi: 10.3390/molecules23061302 Authors: Volodymyr V. Oberemok Kateryna V. Laikova Anna I. ...

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