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208 Newest Publications about the topic pegylation


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Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

23-May-2018 | Kerda Keevend; Guido Panzarasa; Fabian H. L. Starsich; Martin Zeltner; Anastasia Spyrogianni; Elena Tsolaki; Giusepp ..., Chemical Communication, 2018

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the ...


Molecules, Vol. 23, Pages 1008: Nanotechnological Strategies for Protein Delivery

25-Apr-2018 | Villegas, María Rocío; Baeza, Alejandro ; Vallet-Regí, María, Molecules, 2018

Molecules, Vol. 23, Pages 1008: Nanotechnological Strategies for Protein Delivery Molecules doi: 10.3390/molecules23051008 Authors: María Rocío Villegas Alejandro Baeza María Vallet-Regí The use of therapeutic proteins plays a fundamental role in the treatment of numerous ...


Luminescent rhenium(I), ruthenium(II), and iridium(III) polypyridine complexes containing a poly(ethylene glycol) pendant or bioorthogonal reaction group as biological probes and photocytotoxic agents

15-Apr-2018 | Author(s): Alex Man-Hei Yip, Kenneth Kam-Wing Lo, Coordination Chemistry Reviews, 2018

Publication date: 15 April 2018 Source:Coordination Chemistry Reviews, Volume 361 Author(s): Alex Man-Hei Yip, Kenneth Kam-Wing Lo A number of luminescent transition metal complexes display attractive properties such as high photostability, long emission lifetimes, and ...


IJMS, Vol. 19, Pages 1189: A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model

13-Apr-2018 | Rajendrakumar, Santhosh Kalash; Chang, Ning-Chu ; Mohapatra, Adityanarayan ; Uthaman, Saji ; Lee, Byeong-Il ; Tsai, ..., International Journal of Molecular Sciences, 2018

IJMS, Vol. 19, Pages 1189: A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model International Journal of Molecular Sciences doi: ...


A Modularly Designable Vesicle for Sequentially Multiple Loading

28-Dec-2017 | Yiyang Zhang, Dandan Bao, Shuo Wang, Yuancheng Dong, Fen Wu, Haitao Li, Dongsheng Liu, Small, 2017

Abstract The vesicle is one of the most intriguing platforms for drug delivery, which is believed to improve drug efficacy. In the past few decades, a great deal of materials have been explored to make vesicles, including lipids, block copolymers, dendrons, erythrocyte membranes, and even DNA. ...


Byproduct-Free Intact Modification of Insulin by Cholesterol End-Modified Poly(ethylene glycol) for in Vivo Protein Delivery

20-Dec-2017 | Shoichiro Asayama; Kana Nagashima; Yoichi Negishi; Hiroyoshi Kawakami, Bioconjugate Chemistry, 2017

Insulin is a key peptide hormone used for the treatment of both type I and type II diabetes. To maximize the effect of the treatment of these diseases, the addition of poly(ethylene glycol) (PEGylation) methods for the insulin are widely developed. Here, to make these PEGylation methods the ...


Compatibility of PEGylated Polymer Nanoparticles with the Biophysical Function of Lung Surfactant

19-Dec-2017 | Moritz Beck-Broichsitter, Langmuir, 2017

To minimize an unwanted interference of colloidal drug delivery vehicles with the biophysical functionality of lung surfactant, the surface of polymer nanoparticles was modified with poly(ethylene glycol) (PEGylation). Plain poly(lactide) nanoparticles provoked a statistically relevant decrease ...


Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release

18-Dec-2017 | Jiaojie Tan; Tae Joon Cho; De-Hao Tsai; Jingyu Liu; John M. Pettibone; Rian You; Vincent A. Hackley; Michael R. Zach ..., Langmuir, 2017

Cisplatin-complexed gold nanoparticles (PtII–AuNP) provide a promising strategy for chemo-radiation-based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis and its influence on drug payload, stability, and release. ...


MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra

07-Nov-2017 | Lei Yin; Chong Su; Tianming Ren; Xiangjun Meng; Meiyun Shi; J. Paul Fawcett; Mengliang Zhang; Wei Hu; Jingkai Gu, Analyst, 2017

The covalent attachment of polyethylene glycol (PEG) to therapeutic compounds (known as PEGylation) is one of the most promising techniques to improve the biological efficacy of small molecular weight drugs. After administration, PEGylated prodrugs can be metabolized into pharmacologically active ...


Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location

09-Oct-2017 | Steven R. E. Draper; Paul B. Lawrence; Wendy M. Billings; Qiang Xiao; Nathaniel P. Brown; Natalie A. Bécar; Derek J. ..., Bioconjugate Chemistry, 2017

The development of chemical strategies for site-specific protein modification now enables researchers to attach polyethylene glycol (PEG) to a protein drug at one or more specific locations (i.e., protein PEGylation). However, aside from avoiding enzyme active sites or protein-binding interfaces, ...


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