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65 Newest Publications about the topic radiochemistry


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Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure

29-May-2018 | Alice King; Andreas Doepner; David Turton; Daniela M. Ciobota; Chiara Da Pieve; Anne-Christine Wong Te Fong; Gabriel ..., Organic & Biomolecular Chemistry, 2018

Trifluoromethyl groups are widespread in medicinal chemistry, yet there are limited 18F-radiochemistry techniques available for the production of the complementary PET agents. Herein, we report the first radiosynthesis of the anticancer nucleoside analogue trifluridine, using a fully automated, ...


Chemistry and Radiochemistry of Arsenic, Rhenium and Rhodium Isotopes Relevant to Radiopharmaceutical Applications: Development of High Specific Activity Radionuclides for Imaging and Treatment

18-Jan-2018 | Yutian Feng; Tim E. Phelps; Valerie Carroll; Fabio Gallazzi; Gary Sieckman; Timothy J. Hoffman; Charles L. Barnes; A ..., Dalton Transactions, 2018

The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri activities over the past several decades, and includes recent results. The nuclear facilities at the University of Missouri (10 MW research ...


Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors

29-Dec-2017 | Thomas Lee Collier; Steven H. Liang; J. John Mann; Neil Vasdev; J. S. Dileep Kumar, Beilstein Journal of Organic Chemistry, 2017

Abstract Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers. The main advantages of microfluidics are the reduction in reaction times and ...


Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer [Chemistry]

24-Oct-2017 | Jeffrey Collins; Christopher M. Waldmann; Christopher Drake; Roger Slavik; Noel S. Ha; Maxim Sergeev; Mark Lazari; B ..., Proceedings of the National Academy of Sciences current issue, 2017

New radiolabeled probes for positron-emission tomography (PET) are providing an ever-increasing ability to answer diverse research and clinical questions and to facilitate the discovery, development, and clinical use of drugs in patient care. Despite the high equipment and facility costs to ...


Fluorine-18 labelled building blocks for PET tracer synthesis

20-Jun-2017 | Dion van der Born; Anna Pees; Alex J. Poot; Romano V. A. Orru; Albert D. Windhorst; Danielle J. Vugts, Chemical Society Reviews, 2017

Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 ...


Click Chemistry and Radiochemistry: The First 10 Years

22-Nov-2016 | Jan-Philip Meyer; Pierre Adumeau; Jason S. Lewis; Brian M. Zeglis, Bioconjugate Chemistry, 2016

The advent of click chemistry has had a profound influence on almost all branches of chemical science. This is particularly true of radiochemistry and the synthesis of agents for positron emission tomography (PET), single photon emission computed tomography (SPECT), and targeted radiotherapy. The ...


High-Yielding Automated Convergent Synthesis of No-Carrier-Added [11C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction

07-Nov-2016 | Junhao Xing; Allen F. Brooks; Dylan Fink; Huibin Zhang; Morand R. Piert; Peter J. H. Scott; Xia Shao, Synlett, 2016

SynlettDOI: 10.1055/s-0036-1588638 A new variant of the Strecker synthesis using no-carrier-added [11C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET ...


Preparation of No‐Carrier‐Added 6‐[18F]Fluoro‐l‐tryptophan via Cu‐Mediated Radiofluorination

29-Aug-2016 | Dominique Schäfer, Philipp Weiß, Johannes Ermert, Johnny Castillo Meleán, Fadi Zarrad, Bernd Neumaier, European Journal of Organic Chemistry, 2016

18F‐Labeled aromatic amino acids exhibit great potential for diagnostic applications using positron emission tomography. However, the introduction of 18F into aromatic compounds remains challenging, and novel fluorination methods facilitating easy access to 18F‐labeled arenes are highly sought ...


The Active Field of Nuclear and Radiochemistry: Not Just Nuclear Power

20-Jun-2016 | Clemens Walther, Angewandte Chemie International Edition, 2016

“ … The number of universities teaching nuclear and radiochemistry has decreased, not least as radiochemistry is erroneously linked to the use of nuclear power … Radiochemistry is essential for a variety of fields, including radiopharmaceuticals, as well as the management of radioactive waste … ...


Atomic-Scale Picture of the Composition, Decay, and Oxidation of Two-Dimensional Radioactive Films

15-Jan-2016 | Alex Pronschinske; Philipp Pedevilla; Benjamin Coughlin; Colin J. Murphy; Felicia R. Lucci; Matthew A. Payne; Andrew ..., ACS Nano, 2016

Two-dimensional radioactive 125I monolayers are a recent development that combines the fields of radiochemistry and nanoscience. These Au-supported monolayers show great promise for understanding the local interaction of radiation with 2D molecular layers, offer different directions for surface ...


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