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109 Newest Publications about the topic sample handling


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Membrane Electrospray Ionization for Direct Ultrasensitive Biomarker Quantitation in Biofluids Using Mass Spectrometry

03-Mar-2015 | Mei Zhang; Fankai Lin; Jianguo Xu; Wei Xu, Analytical Chemistry, 2015

The ability of rapid biomarker quantitation in raw biological samples would expand the application of mass spectrometry in clinical diagnosis. Up until now, the conventional chromatography–mass spectrometry method is time-consuming in both sample preparation and chromatography separation ...


Development of Cyclic NGR Peptides with Thioether Linkage: Structure and Dynamics Determining Deamidation and Bioactivity

16-Feb-2015 | Kata Nóra Enyedi; András Czajlik; Krisztina Knapp; András Láng; Zsuzsa Majer; Eszter Lajkó; László Kőhidai; András P ..., Journal of Medicinal Chemistry, 2015

NGR peptides that recognize CD13 receptors in tumor neovasculature are of high interest, in particular due to their potential applications in drug targeting. Here we report the synthesis and structural analysis of novel thioether bond-linked cyclic NGR peptides. Our results show that their ...


Membrane funnel‐based spray ionization for protein/peptide analysis by Fourier transform ion cyclotron resonance mass spectrometry

15-Jan-2015 | Hoi Sze Yeung, Wan Li, Ze Wang, Y. L. Elaine Wong, Xiangfeng Chen, T.‐W. Dominic Chan, Rapid Communications in Mass Spectrometry, 2015

RATIONALE Samples analyzed in proteomic studies by nanoelectrospray ionization (nanoESI) are extremely limited in quantity requiring careful sample handling to prevent loss upon transfer and to maintain sample concentration. To alleviate the operational process and reduce the cost of nanoESI, ...


An emerging approach for the targeting analysis of dimethoate in olive oil: The role of molecularly imprinted polymers based on photo-iniferter induced “living” radical polymerization

21-Dec-2014 | Author(s): Nuno Martins , Elisabete P. Carreiro , Marco Simões , Maria João Cabrita , Anthony J. Burke , Raquel ..., Reactive and Functional Polymers, 2014

Publication date: January 2015 Source:Reactive and Functional Polymers, Volume 86 Author(s): Nuno Martins , Elisabete P. Carreiro , Marco Simões , Maria João Cabrita , Anthony J. Burke , Raquel Garcia This study concerns the first attempt to prepare molecularly imprinted polymers for ...


Identification of plasma protease derived metabolites of glucagon and their formation under typical laboratory sample handling conditions

15-Dec-2014 | James W. Howard, Richard G. Kay, Tricia Tan, James Minnion, Colin S. Creaser, Rapid Communications in Mass Spectrometry, 2014

RATIONALE Glucagon modulates glucose production, and it is also a biomarker for several pathologies. It is known to be unstable in human plasma, and consequently stabilisers are often added to samples, although these are not particularly effective. Despite this, there have not been any studies ...


Membrane Introduction Mass Spectrometry (MIMS): A Versatile Tool for Direct, Real‐Time Chemical Measurements

04-Dec-2014 | E. T. Krogh, C. G. Gill, Journal of Mass Spectrometry, 2014

Membrane introduction (or inlet) mass spectrometry (MIMS) is a direct, on‐line analytical technique, requiring that the mass spectrometer resolve analytes in the mixture based upon their m/z, their ionization characteristics and/or by mass spectrometry techniques. The coupling of semi‐permeable ...


Quantification of the information in small‐angle scattering data

01-Dec-2014 | Martin Cramer Pedersen, Steen Laugesen Hansen, Bo Markussen, Lise Arleth, Kell Mortensen, Journal of Applied Crystallography, 2014

Small‐angle X‐ray and neutron scattering have become increasingly popular owing to improvements in instrumentation and developments in data analysis, sample handling and sample preparation. For some time, it has been suggested that a more systematic approach to the quantification of the ...


Self-Digitization Microfluidic Chip for Absolute Quantification of mRNA in Single Cells

25-Nov-2014 | Alison M. Thompson; Alexander Gansen; Amy L. Paguirigan; Jason E. Kreutz; Jerald P. Radich; Daniel T. Chiu, Analytical Chemistry, 2014

Quantification of mRNA in single cells provides direct insight into how intercellular heterogeneity plays a role in disease progression and outcomes. Quantitative polymerase chain reaction (qPCR), the current gold standard for evaluating gene expression, is insufficient for providing absolute ...


Thymol treatment of bacteria prior to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level

24-Oct-2014 | Ricky D. Holland, Jon G. Wilkes, Willie M. Cooper, Pierre Alusta, Anna Williams, Bruce Pearce, Michael Beaudoin, Dan ..., Rapid Communications in Mass Spectrometry, 2014

RATIONALE The identification of bacteria based on mass spectra produced by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) has become routine since its introduction in 1996. The major drawback is that bacterial patterns produced by MALDI are dependent ...


Simultaneous Assessment of Kinetic, Site‐Specific, and Structural Aspects of Enzymatic Protein Phosphorylation

09-Jul-2014 | Michiel van de Waterbeemd, Philip Lössl, Violette Gautier, Fabio Marino, Masami Yamashita, Elena Conti, Arjen Scholt ..., Angewandte Chemie International Edition, 2014

Abstract Protein phosphorylation is a widespread process forming the mechanistic basis of cellular signaling. Up to now, different aspects, for example, site‐specificity, kinetics, role of co‐factors, and structure–function relationships have been typically investigated by multiple techniques ...


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