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95 Newest Publications about the topic warfarin

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Sudden Death by Spontaneous Epiglottic Hematoma Secondary to High Blood Levels of Warfarin

01-Jun-2017 | Séverine Gilard‐Pioc, Pascal Guerard, François Paraf, Irène François‐Purssell, Journal of Forensic Sciences, 2017

Abstract A 67‐year‐old man was found dead, at his home. On external examination, we found a voluminous purplish black ecchymosis of the anterior neck area. On internal examination, we found a voluminous epiglottis hematoma completely obstructing the upper airway. It was associated with other ...

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Molecules, Vol. 22, Pages 314: Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin

18-Feb-2017 | Ikeda, Masaki ; Ueda-Wakagi, Manabu ; Hayashibara, Kaori ; Kitano, Rei ; Kawase, Masaya ; Kaihatsu, Kunihiro ; Kato, ..., Molecules, 2017

It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and ...

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Warfarin genotyping with hybridization-induced aggregation on a poly(ethylene terephthalate) microdevice

28-Dec-2016 | Hillary S. Sloane; Morgan B. Carter; Alexa E. C. Cecil; Delphine Le Roux; Daniel L. Mills; James P. Landers, Analyst, 2016

Warfarin, a commonly prescribed oral anticoagulant, is burdened by a narrow therapeutic index and high inter-individual variability in response, making it the second leading cause of drug-related emergency room visits. Since genetic factors contribute significantly to warfarin sensitivity, a ...

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Warfarin genotyping with hybridization-induced aggregation on a poly(ethylene terephthalate) microdevice

20-Dec-2016 | Hillary S. Sloane; Morgan B. Carter; Alexa E. C. Cecil; Delphine Le Roux; Daniel L. Mills; James P. Landers, Analyst, 2016

Warfarin, a commonly prescribed oral anticoagulant, is burdened by a narrow therapeutic index and high inter-individual variability in response, making it the second leading cause of drug-related emergency room visits. Since genetic factors contribute significantly to warfarin sensitivity, a ...

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Synthesis, electronic structure and molecular docking of new organometallic palladium (II) complexes with intercalator lignads: The influence of bridged ligands on enhanced DNA/serum protein binding and in vitro antitumoral activity

06-Nov-2016 | Author(s): Kazem Karami, Zohreh Mehri Lighvan, Maryam Dehdashti Jahromi, Janusz Lipkowski, Amir Abbas Momt ..., Journal of Organometallic Chemistry, 2016

Publication date: 1 January 2017 Source:Journal of Organometallic Chemistry, Volume 827 Author(s): Kazem Karami, Zohreh Mehri Lighvan, Maryam Dehdashti Jahromi, Janusz Lipkowski, Amir Abbas Momtazi-borojeni Novel organometallic palladium(II) complexes ...

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Probing the Sudlow binding site with warfarin: how does gold nanocluster growth alter human serum albumin?

16-Aug-2016 | B. A. Russell; P. A. Mulheran; D. J. S. Birch; Y. Chen, Physical Chemistry Chemical Physics, 2016

The search for new fluorescent molecules is vital to the advancement of molecular imaging and sensing for the benefit of medical and biological studies. One such class of new fluorescent molecule is fluorescent gold nanoclusters encapsulated in Human Serum Albumin (HSA-AuNC). In order to use this ...

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Elucidation of the interaction of human serum albumin with anti‐cancer sipholane triterpenoid from the Red Sea sponge

16-Jun-2016 | Mohd. Sajid Ali, Musarat Amina, Hamad A. Al‐Lohedan, Nawal M. Al Musayeib, Luminescence, 2016

Abstract A sipholane triterpenoid, named sipholenone A, with anti‐cancer properties was isolated from the Red Sea sponge Siphonochalina siphonella and characterized by proton and carbon‐13 nuclear magnetic resonance (1H NMR and 13C NMR) spectroscopies. The goal of this study was to visualize ...

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The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

31-May-2016 | Douglas L. Feinstein, Belinda S. Akpa, Manuela A. Ayee, Anne I. Boullerne, David Braun, Sergey V. Brodsky, David Gid ..., Annals of the New York Academy of Sciences, 2016

Superwarfarins were developed following the emergence of warfarin resistance in rodents. Compared to warfarin, superwarfarins have much longer half‐lives and stronger affinity to vitamin K epoxide reductase and therefore can cause death in warfarin‐resistant rodents. By the mid‐1970s, the ...

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Exploiting Cosolubilization of Warfarin, Curcumin and Rhodamine B for Modulation of Energy Transfer‐ A micelle FRET "On/Off" switch

28-Apr-2016 | Parvaiz Ahmad Bhat, Oyais Ahmad Chat, Aijaz Ahmad Dar, ChemPhysChem, 2016

Here in we introduce two new FRET pairs comprising of Warfarin, Curcumin, and Rhodamine B using surfactant based self‐assembled soft systems as scaffolds. Extension of the study was made to design a two‐step concurrent FRET system based on such three fluorophores, an important mechanism to ...

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Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales

29-Mar-2016 | Liang, Guyan; Phillip Bowen, J., Current Topics in Medicinal Chemistry, 2016

Abstract: There has been a revolution in the development of effective, small-molecule anticoagulants and antiplatelet agents. Numerous trypsin-like serine proteases have been under active pursuit as therapeutic targets. Important examples include thrombin, factor VIIa, factor Xa, and ...

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