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95 Newest Publications about the topic warfarin

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Investigation of the binding of cis/trans-[MCl4(1H-indazole)(NO)]− (M = Ru, Os) complexes to human serum albumin

13-Mar-2016 | Author(s): Orsolya Dömötör, Anna Rathgeb, Paul-Steffen Kuhn, Ana Popović-Bijelić, Goran Bačić, Eva Anna ..., Journal of Inorganic Biochemistry, 2016

Publication date: June 2016 Source:Journal of Inorganic Biochemistry, Volume 159 Author(s): Orsolya Dömötör, Anna Rathgeb, Paul-Steffen Kuhn, Ana Popović-Bijelić, Goran Bačić, Eva Anna Enyedy, Vladimir B. Arion Overall binding affinity of sodium or indazolium ...

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Molecules, Vol. 21, Pages 54: DNA Binding, Photonuclease Activity and Human Serum Albumin Interaction of a Water-Soluble Freebase Carboxyl Corrole

31-Dec-2015 | Na, Ning ; Zhao, Da-Qiang ; Li, Heng ; Jiang, Nan ; Wen, Jin-Yan ; Liu, Hai-Yang, Molecules, 2015

The DNA binding property of 5,10,15-Tris(4-carboxyphenyl) corrole (TCPC) was studied by UV-Visible, fluorescence and circular dichroism (CD) spectroscopic methods. TCPC can bind to ct-DNA via an outside binding mode with the binding constant of Kb = 1.05 × 105 M−1. TCPC also displayed good ...

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A fully integrated and automated microsystem for rapid pharmacogenetic typing of multiple warfarin-related single-nucleotide polymorphisms

01-Dec-2015 | Bin Zhuang; Junping Han; Guangxin Xiang; Wupeng Gan; Shuaiqin Wang; Dong Wang; Lei Wang; Jing Sun; Cai-Xia Li; Peng Liu, Lab on a Chip, 2015

A fully integrated and automated microsystem consisting of low-cost, disposable plastic chips for DNA extraction and PCR amplification combined with a reusable glass capillary array electrophoresis chip in a modular-based format was successfully developed for warfarin pharmacogenetic testing. DNA ...

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IJMS, Vol. 16, Pages 27550-27560: Improvement of Psychotic Symptoms and the Role of Tissue Plasminogen Activator

18-Nov-2015 | Hoirisch-Clapauch, Silvia ; Nardi, Antonio E., International Journal of Molecular Sciences, 2015

Tissue plasminogen activator (tPA) mediates a number of processes that are pivotal for synaptogenesis and remodeling of synapses, including proteolysis of the brain extracellular matrix, degradation of adhesion molecules, activation of neurotrophins, and activation of the N-methyl-d-aspartate ...

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Hyphenation of Hadamard Encoded Multiplexing Liquid Chromatography and Circular Dichroism Detection to Improve the Signal-to-Noise Ratio in Chiral Analysis

18-Nov-2015 | Alexander F. Siegle; Oliver Trapp, Analytical Chemistry, 2015

The hyphenation of HPLC and circular dichroism (CD) detection is a useful analytical tool that can significantly facilitate the analysis (e.g., the assignment of the configuration) and quantitation of chiral compounds. HPLC-CD chromatograms often exhibit a low signal-to-noise ratio compared to ...

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A fully integrated and automated microsystem for rapid pharmacogenetic typing of multiple warfarin-related single-nucleotide polymorphisms

10-Nov-2015 | Bin Zhuang; Junping Han; Guangxin Xiang; Wupeng Gan; Shuaiqin Wang; Dong Wang; Lei Wang; Jing Sun; Cai-xia Li; Peng Liu, Lab on a Chip, 2015

A fully integrated and automated microsystem consisting of low-cost, disposable plastic chips for DNA extraction and PCR amplification combined with a reusable glass capillary array electrophoresis chip in a modular-based format was successfully developed for warfarin pharmacogenetic testing. DNA ...

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Membrane Composition Influences the Activity of in Vitro Refolded Human Vitamin K Epoxide Reductase

09-Oct-2015 | Frank Jaenecke; Beatrice Friedrich-Epler; Christoph Parthier; Milton T. Stubbs, Biochemistry, 2015

Human vitamin K epoxide reductase (hVKOR) is an integral membrane protein responsible for the maintenance of reduced vitamin K pools, a prerequisite for the action of γ-glutamyl carboxylase and hence for hemostasis. Here we describe the recombinant expression of hVKOR as an insoluble fusion ...

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Tautomerism of Warfarin: Combined Chemoinformatics, Quantum Chemical, and NMR Investigation

25-Sep-2015 | Laura Guasch; Megan L. Peach; Marc C. Nicklaus, The Journal of Organic Chemistry, 2015

Warfarin, an important anticoagulant drug, can exist in solution in 40 distinct tautomeric forms through both prototropic tautomerism and ring–chain tautomerism. We have investigated all warfarin tautomers with computational and NMR approaches. Relative energies calculated at the ...

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Influence of ligand binding on structure and thermostability of human α1‐acid glycoprotein

24-Sep-2015 | Vladimír Kopecký, Rüdiger Ettrich, Tomáš Pazderka, Kateřina Hofbauerová, David Řeha, Vladimír Baumruk, Journal of Molecular Recognition, 2015

Ligand binding of neutral progesterone, basic propranolol, and acidic warfarin to human α1‐acid glycoprotein (AGP) was investigated by Raman spectroscopy. The binding itself is characterized by a uniform conformational shift in which a tryptophan residue is involved. Slight differences ...

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Combined use of cyclofructans and an amino acid‐based ionic liquid for the enantioseparation of huperzine a and coumarin derivatives in CE

07-Sep-2015 | Ioannis J. Stavrou, Zachary S. Breitbach, Constantina P. Kapnissi‐Christodoulou, ELECTROPHORESIS, 2015

Cyclofructans (CFs) and their derivatives have recently been proven to be efficient chiral selectors (CSs) for the enantioseparation of several analytes in CE, HPLC and GC. In this study, the chiral separation ability of a number of native and derivatized CFs was examined in CE. Particularly, ...

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